den Boon JA, Diaz A, Ahlquist P
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Cytoplasmic viral replication complexes.
Cell Host Microbe. 2010 Jul 22;8(1):77-85
Authors: den Boon JA, Diaz A, Ahlquist P
Many viruses that replicate in the cytoplasm compartmentalize their genome replication and transcription in organelle-like structures that enhance replication efficiency and protection from host defenses. In particular, recent studies with diverse positive-strand RNA viruses have further elucidated the ultrastructure of membrane-bound RNA replication complexes and how these complexes function in close coordination with virion assembly and budding. The structure, function, and assembly of some positive-strand RNA virus replication complexes have parallels and potential evolutionary links with the replicative cores of double-strand RNA virus and retrovirus virions and more general similarities with the replication factories of cytoplasmic DNA viruses.
PMID: 20638644 [PubMed - in process]
