Direct Complement Restriction of Flavivirus Infection Requires Glycan Recognition by Mannose-Binding Lectin

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CELL HOST AND MICROBE

Anja Fuchs, Tsai-Yu Lin, David W. Beasley, Cordula M. Stover, Wilhelm J. Schwaeble, Theodore C. Pierson, Michael S. Diamond. An intact complement system is crucial for limiting West Nile virus (WNV) dissemination. Herein, we define how complement directly restricts flavivirus infection in an antibody-independent fashion....