Taxman DJ, Huang MT, Ting JP
Inflammasome inhibition as a pathogenic stealth mechanism.
Cell Host Microbe. 2010 Jul 22;8(1):7-11
Authors: Taxman DJ, Huang MT, Ting JP
The activation of inflammasomes containing NBD-LRR (NLRs) or non-NLRs is critical for effective host defense against microbial pathogens. Recent discoveries have uncovered a plethora of pathogenic strategies to inhibit inflammasome-mediated processing of IL-1beta and IL-18. We review recent evidence for viral and bacterial manipulation of the inflammasome, ranging from perturbation of caspase-1 activation to targeting of specific inflammasome components.
PMID: 20638636 [PubMed - in process]