The Human Immune Response to Dengue Virus Is Dominated by Highly Cross-Reactive Antibodies Endowed with Neutralizing and Enhancing Activity

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CELL HOST AND MICROBE

Martina Beltramello, Katherine L. Williams, Cameron P. Simmons, Annalisa Macagno, Luca Simonelli, Nguyen Than Ha Quyen, Soila Sukupolvi-Petty, Erika Navarro-Sanchez, Paul R. Young, Aravinda M. de Silva, Félix A. Rey, Luca Varani, Stephen S. Whitehead, Michael S. Diamond, Eva Harris, Antonio Lanzavecchia, Federica Sallusto. Antibodies protect against homologous Dengue virus (DENV) infection but can precipitate severe dengue by promoting heterotypic virus entry via Fc? receptors (Fc?R). We immortalized m....