The N-terminal domain of Aliivibrio fischeri LuxR is a target of the GroEL chaperonin.

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Manukhov IV, Melkina OE, Goryanin II, Baranova AV, Zavilgelsky GB

The N-terminal domain of Aliivibrio fischeri LuxR is a target of the GroEL chaperonin.

J Bacteriol. 2010 Oct;192(20):5549-51

Authors: Manukhov IV, Melkina OE, Goryanin II, Baranova AV, Zavilgelsky GB

Here we show that the C-terminal domain of LuxR activates the transcription of Aliivibrio fischeri luxICDABEG in Escherichia coli SKB178 gro(+) and E. coli OFB1111 groEL673 strains to the same level. Using affinity chromatography, we showed that GroEL binds to the N-terminal domain of LuxR, pointing to a GroEL/GroES requirement for the folding of the N-terminal domain of LuxR.

PMID: 20729362 [PubMed - in process]