Zhang X, Bertaso F, Yoo JW, Baumgärtel K, Clancy SM, Lee V, Cienfuegos C, Wilmot C, Avis J, Hunyh T, Daguia C, Schmedt C, Noebels J, Jegla T
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Deletion of the potassium channel Kv12.2 causes hippocampal hyperexcitability and epilepsy.
Nat Neurosci. 2010 Sep;13(9):1056-8
Authors: Zhang X, Bertaso F, Yoo JW, Baumgärtel K, Clancy SM, Lee V, Cienfuegos C, Wilmot C, Avis J, Hunyh T, Daguia C, Schmedt C, Noebels J, Jegla T
We found the voltage-gated K(+) channel Kv12.2 to be a potent regulator of excitability in hippocampal pyramidal neurons. Genetic deletion and pharmacologic block of Kv12.2 substantially reduced the firing threshold of these neurons. Kv12.2(-/-) (also known as Kcnh3(-/-)) mice showed signs of persistent neuronal hyperexcitability including frequent interictal spiking, spontaneous seizures and increased sensitivity to the chemoconvulsant pentylenetetrazol.
PMID: 20676103 [PubMed - in process]
