G?5 recruits R7 RGS proteins to GIRK channels to regulate the timing of neuronal inhibitory signaling

Keqiang Xie, Kevin L Allen, Saïd Kourrich, José Colón-Saez, Mark J Thomas, Kevin Wickman & Kirill A Martemyanov

The type 5 G protein ? subunit (G?5) can form complexes with members of the regulator of G protein signaling 7 (RGS7) family, but its relevance to neuronal G protein signaling is unclear. We found that mouse RGS7-G?5 complexes bound to G protein–gated potassium channels and facilitated their functional coupling to GABA_B receptors in neurons. Our findings identify a compartmentalization mechanism that is critical for ensuring high temporal resolution of neuronal G protein signaling.