Mitochondrial Dysfunction in NnaD Mutant Flies and Purkinje Cell Degeneration Mice Reveals a Role for Nna Proteins in Neuronal Bioenergetics

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Lisa Chakrabarti, Rabaab Zahra, Stephen M. Jackson, Parsa Kazemi-Esfarjani, Bryce L. Sopher, Amanda G. Mason, Thomas Toneff, Soyoung Ryu, Scott Shaffer, Janice W. Kansy, Jeremiah Eng, Gennifer Merrihew, Michael J. MacCoss, Anne Murphy, David R. Goodlett, Vivian Hook, Craig L. Bennett, Leo J. Pallanck, Albert R. La Spada. The Purkinje cell degeneration (pcd) mouse is a recessive model of neurodegeneration, involving cerebellum and retina. Purkinje cell death in pcd is dramatic, as >99% of Purkinje ....