Celia JA Morgan
Cannabidiol Attenuates the Appetitive Effects of Δ9-Tetrahydrocannabinol in Humans Smoking Their Chosen Cannabis
Neuropsychopharmacology 35, 1879 (August 2010). doi:10.1038/npp.2010.58
Authors: Celia JA Morgan, Tom P Freeman, Gráinne L Schafer & H Valerie Curran
Keywords: Cannabinoids; Addiction & Substance Abuse; Psychopharmacology; Cognition; Attention bias; THC; cannabidiol; cannabis; dependence
One of the issues with the methodology is the self-selection. In particular it is not made clear that in the underlying population the selection of different types of cannabis preparations is random. Certainly in the US, the high delta9THC:cannabidiol strains dominate, according to El Sohly’s data on seized samples anyway. The higher cannabidiol materials appear to be exceptionally rare. In this paper, the categories of skunk, herbal and resinous material differ in the cannabidiol content. This raises the question of very distinct user groups who either have access to, or prefer and seek, the different ratio materials.
Until such questions about the underlying user populations are satisfied it is really difficult to conclude that there is anything clearly associated with the THC/cannabidiol ratio.
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