Patricia M. Day, Rhonda C. Kines, Cynthia D. Thompson, Subhashini Jagu, Richard B. Roden, Douglas R. Lowy, John T. Schiller. Using a human papillomavirus (HPV) cervicovaginal murine challenge model, we microscopically examined the in vivo mechanisms o… . . . → Read More: In Vivo Mechanisms of Vaccine-Induced Protection against HPV Infection
Wendy S. Garrett, Carey A. Gallini, Tanya Yatsunenko, Monia Michaud, Andrea DuBois, Mary L. Delaney, Shivesh Punit, Maria Karlsson, Lynn Bry, Jonathan N. Glickman, Jeffrey I. Gordon, Andrew B. Onderdonk, Laurie H. Glimcher. Disruption of homeostasis be… . . . → Read More: Enterobacteriaceae Act in Concert with the Gut Microbiota to Induce Spontaneous and Maternally Transmitted Colitis
Martina Beltramello, Katherine L. Williams, Cameron P. Simmons, Annalisa Macagno, Luca Simonelli, Nguyen Than Ha Quyen, Soila Sukupolvi-Petty, Erika Navarro-Sanchez, Paul R. Young, Aravinda M. de Silva, Félix A. Rey, Luca Varani, Stephen S. Whitehea… . . . → Read More: The Human Immune Response to Dengue Virus Is Dominated by Highly Cross-Reactive Antibodies Endowed with Neutralizing and Enhancing Activity
Tokiko Watanabe, Shinji Watanabe, Yoshihiro Kawaoka. Influenza viruses cause epidemics and pandemics. Like all viruses, influenza viruses rely on the host cellular machinery to support their life cycle. Accordingly, identification of the host functi…. . . . → Read More: Cellular Networks Involved in the Influenza Virus Life Cycle
Paul D. Bieniasz. Recent work has illuminated three critical aspects of the cell biology of HIV-1 particle genesis. First, we have come to understand which cellular membranes are selected as platforms for virus par…. . . . → Read More: The Cell Biology of HIV-1 Virion Genesis
Rachel D. Hood, Pragya Singh, FoSheng Hsu, Tüzün Güvener, Mike A. Carl, Rex R.S. Trinidad, Julie M. Silverman, Brooks B. Ohlson, Kevin G. Hicks, Rachael L. Plemel, Mo Li, Sandra Schwarz, Wenzhuo Y. Wang, Alexey J. Merz, David R. Goodlett, Joseph D. … . . . → Read More: A Type VI Secretion System of Pseudomonas aeruginosa Targets a Toxin to Bacteria
Jeffery K. Taubenberger, John C. Kash. Newly emerging or “re-emerging” viral diseases continue to pose significant global public health threats. Prototypic are influenza viruses that are major causes of human respiratory infections and…. . . . → Read More: Influenza Virus Evolution, Host Adaptation, and Pandemic Formation
David L. Moyes, Manohursingh Runglall, Celia Murciano, Chengguo Shen, Deepa Nayar, Selvam Thavaraj, Arinder Kohli, Ayesha Islam, Hector Mora-Montes, Stephen J. Challacombe, Julian R. Naglik. Discriminating between commensal and pathogenic states of opp… . . . → Read More: A Biphasic Innate Immune MAPK Response Discriminates between the Yeast and Hyphal Forms of Candida albicans in Epithelial Cells
David C. Goldstone, Melvyn W. Yap, Laura E. Robertson, Lesley F. Haire, William R. Taylor, Aris Katzourakis, Jonathan P. Stoye, Ian A. Taylor. Lentiviruses are widespread in a variety of vertebrates, often associated with chronic disease states. Howeve… . . . → Read More: Structural and Functional Analysis of Prehistoric Lentiviruses Uncovers an Ancient Molecular Interface
Shahab Shahnazari, Wei-Lien Yen, Cheryl L. Birmingham, Jessica Shiu, Anton Namolovan, Yiyu T. Zheng, Keiko Nakayama, Daniel J. Klionsky, John H. Brumell. Autophagy mediates the degradation of cytoplasmic contents in the lysosome and plays a significant… . . . → Read More: A Diacylglycerol-Dependent Signaling Pathway Contributes to Regulation of Antibacterial Autophagy
Lucia Peixoto, Feng Chen, Omar S. Harb, Paul H. Davis, Daniel P. Beiting, Catie Small Brownback, Dinkorma Ouloguem, David S. Roos. Apicomplexan parasites release factors via specialized secretory organelles (rhoptries, micronemes) that are thought to c… . . . → Read More: Integrative Genomic Approaches Highlight a Family of Parasite-Specific Kinases that Regulate Host Responses
Kevin J. Sokoloski, Alexa M. Dickson, Emily L. Chaskey, Nicole L. Garneau, Carol J. Wilusz, Jeffrey Wilusz. How viral transcripts are protected from the cellular RNA decay machinery and the importance of this protection for the virus are largely unknow… . . . → Read More: Sindbis Virus Usurps the Cellular HuR Protein to Stabilize Its Transcripts and Promote Productive Infections in Mammalian and Mosquito Cells
Anja Fuchs, Tsai-Yu Lin, David W. Beasley, Cordula M. Stover, Wilhelm J. Schwaeble, Theodore C. Pierson, Michael S. Diamond. An intact complement system is crucial for limiting West Nile virus (WNV) dissemination. Herein, we define how complement direc… . . . → Read More: Direct Complement Restriction of Flavivirus Infection Requires Glycan Recognition by Mannose-Binding Lectin
William E. O’Gorman, Padma Sampath, Erin F. Simonds, Rachel Sikorski, Mark O’Malley, Peter O. Krutzik, Hannah Chen, Vijay Panchanathan, Geeta Chaudhri, Gunasegaran Karupiah, David B. Lewis, Steve H. Thorne, Garry P. Nolan. Vaccinia immunization was piv… . . . → Read More: Alternate Mechanisms of Initial Pattern Recognition Drive Differential Immune Responses to Related Poxviruses
Meredith M. Curtis, Emily Rowell, Shahin Shafiani, Amina Negash, Kevin B. Urdahl, Christopher B. Wilson, Sing Sing Way. The degree of lineage stability achieved by pathogen-specific CD4+ T cells in vivo, and how this impacts host defense against infe… . . . → Read More: Fidelity of Pathogen-Specific CD4+ T Cells to the Th1 Lineage Is Controlled by Exogenous Cytokines, Interferon-? Expression, and Pathogen Lifestyle
Sukumar Saha, Xuefang Jing, Shin Yong Park, Shiyong Wang, Xinna Li, Dipika Gupta, Roman Dziarski. There are multiple mechanisms that protect the intestine from an excessive inflammatory response to intestinal microorganisms. We report here that all fou… . . . → Read More: Peptidoglycan Recognition Proteins Protect Mice from Experimental Colitis by Promoting Normal Gut Flora and Preventing Induction of Interferon-?
Lionel B. Ivashkiv. In this issue of Cell Host & Microbe, O’Gorman et al. (2010) identify a key role for early TLR2-mediated IL-6 production and STAT3 activation in generating protective immunity against p…. . . . → Read More: STAT Activation during Viral Infection In Vivo: Where’s the Interferon?
Stephen Rubino, Jooeun Lee, Stephen E. Girardin. Peptidoglycan recognition proteins (PGRPs or Pglyrps) regulate antibacterial responses in Drosophila, yet their functions in humans remain unclear. In this issue of Cell Host & Micro…. . . . → Read More: Mammalian PGRPs Also Mind the Fort
Frank Lafont. Autophagy can orchestrate innate immune responses to bacterial infection by targeting invading pathogens for lysosomal degradation. In this issue of Cell Host & Microbe, Shahnazari et a…. . . . → Read More: Autophagy Employs a New DAGger against Bacteria
Viral suppressors of RNA-based viral immunity: host targets.
Cell Host Microbe. 2010 Jul 22;8(1):12-5
Authors: Wu Q, Wang X, Ding SW
RNA-based viral immunity (RVI) operates in fungi, plants, and inve… . . . → Read More: Viral suppressors of RNA-based viral immunity: host targets.
Inflammasome inhibition as a pathogenic stealth mechanism.
Cell Host Microbe. 2010 Jul 22;8(1):7-11
Authors: Taxman DJ, Huang MT, Ting JP
The activation of inflammasomes containing NBD-LRR (NLRs) or … . . . → Read More: Inflammasome inhibition as a pathogenic stealth mechanism.
Type VI secretion: not just for pathogenesis anymore.
Cell Host Microbe. 2010 Jul 22;8(1):2-6
Authors: Jani AJ, Cotter PA
Type VI secretion systems (T6SS) have been studied primarily in the context o… . . . → Read More: Type VI secretion: not just for pathogenesis anymore.
A place to call home.
Cell Host Microbe. 2010 Jul 22;8(1):1
PMID: 20638634 [PubMed - in process]
. . . → Read More: A place to call home.
Immune evasion and counteraction of restriction factors by HIV-1 and other primate lentiviruses.
Cell Host Microbe. 2010 Jul 22;8(1):55-67
Authors: Kirchhoff F
Retroviruses have evolved effective str… . . . → Read More: Immune evasion and counteraction of restriction factors by HIV-1 and other primate lentiviruses.
Manipulation of host cell death pathways during microbial infections.
Cell Host Microbe. 2010 Jul 22;8(1):44-54
Authors: Lamkanfi M, Dixit VM
Viral and microbial infections often elicit programmed ce… . . . → Read More: Manipulation of host cell death pathways during microbial infections.
The blessings and curses of intestinal inflammation.
Cell Host Microbe. 2010 Jul 22;8(1):36-43
Authors: Winter SE, Keestra AM, Tsolis RM, BÃ¤umler AJ
The intestinal immune system has to strike a de… . . . → Read More: The blessings and curses of intestinal inflammation.
Bacterial interactions with the host epithelium.
Cell Host Microbe. 2010 Jul 22;8(1):20-35
Authors: Kim M, Ashida H, Ogawa M, Yoshikawa Y, Mimuro H, Sasakawa C
The gastrointestinal epithelium deploys… . . . → Read More: Bacterial interactions with the host epithelium.
Imaging parasites at different scales.
Cell Host Microbe. 2010 Jul 22;8(1):16-9
Authors: Frischknecht F
Pathogens interact with their hosts at different spatial and temporal scales. Studying these in… . . . → Read More: Imaging parasites at different scales.
Cytoplasmic viral replication complexes.
Cell Host Microbe. 2010 Jul 22;8(1):77-85
Authors: den Boon JA, Diaz A, Ahlquist P
Many viruses that replicate in the cytoplasm compartmentalize their genome … . . . → Read More: Cytoplasmic viral replication complexes.
Mycobacterium tuberculosis wears what it eats.
Cell Host Microbe. 2010 Jul 22;8(1):68-76
Authors: Russell DG, VanderVen BC, Lee W, Abramovitch RB, Kim MJ, Homolka S, Niemann S, Rohde KH
Mycobacterium… . . . → Read More: Mycobacterium tuberculosis wears what it eats.
Viral latency and its regulation: lessons from the gamma-herpesviruses.
Cell Host Microbe. 2010 Jul 22;8(1):100-15
Authors: Speck SH, Ganem D
Latency is a state of cryptic viral infection associated … . . . → Read More: Viral latency and its regulation: lessons from the gamma-herpesviruses.
Evolution of eukaryotic microbial pathogens via covert sexual reproduction.
Cell Host Microbe. 2010 Jul 22;8(1):86-99
Authors: Heitman J
Sexual reproduction enables eukaryotic organisms to reassort g… . . . → Read More: Evolution of eukaryotic microbial pathogens via covert sexual reproduction.
Regulatory RNA in bacterial pathogens.
Cell Host Microbe. 2010 Jul 22;8(1):116-27
Authors: Papenfort K, Vogel J
Bacteria constitute a large and diverse class of infectious agents, causing devastating… . . . → Read More: Regulatory RNA in bacterial pathogens.
Sebastian E. Winter, A. Marijke Keestra, Renée M. Tsolis, Andreas J. Bäumler. The intestinal immune system has to strike a delicate balance between initiating inflammatory responses against invading bacterial pathogens and avoiding their induction ag… . . . → Read More: The Blessings and Curses of Intestinal Inflammation
Qingfa Wu, Xianbing Wang, Shou-Wei Ding. RNA-based viral immunity (RVI) operates in fungi, plants, and invertebrates to specifically destroy viral RNAs using the cellular RNA interference machinery. Discovery of diverse viral proteins as…. . . . → Read More: Viral Suppressors of RNA-Based Viral Immunity: Host Targets
Minsoo Kim, Hiroshi Ashida, Michinaga Ogawa, Yuko Yoshikawa, Hitomi Mimuro, Chihiro Sasakawa. The gastrointestinal epithelium deploys multiple innate defense mechanisms to fight microbial intruders, including epithelial integrity, rapid epithelial cell… . . . → Read More: Bacterial Interactions with the Host Epithelium
Debra J. Taxman, Max T.-H. Huang, Jenny P.-Y. Ting. The activation of inflammasomes containing NBD-LRR (NLRs) or non-NLRs is critical for effective host defense against microbial pathogens. Recent discoveries have uncovered a plethora of pathogenic…. . . . → Read More: Inflammasome Inhibition as a Pathogenic Stealth Mechanism
Friedrich Frischknecht. Pathogens interact with their hosts at different spatial and temporal scales. Studying these interactions therefore requires a wide range of imaging tools and approaches that bridge physics and bi…. . . . → Read More: Imaging Parasites at Different Scales
Mohamed Lamkanfi, Vishva M. Dixit. Viral and microbial infections often elicit programmed cell death as part of the host defense system or as a component of the survival strategy of the pathogen. It is thus not surprising that path…. . . . → Read More: Manipulation of Host Cell Death Pathways during Microbial Infections
David G. Russell, Brian C. VanderVen, Wonsik Lee, Robert B. Abramovitch, Mi-jeong Kim, Susanne Homolka, Stefan Niemann, Kyle H. Rohde. Mycobacterium tuberculosis remains one of the most pernicious of human pathogens. Current vaccines are ineffective, a… . . . → Read More: Mycobacterium tuberculosis Wears What It Eats
Frank Kirchhoff. Retroviruses have evolved effective strategies to evade the host immune response, such as high variability and latent infection. In addition, primate lentiviruses, such as HIV-1, have acquired sev…. . . . → Read More: Immune Evasion and Counteraction of Restriction Factors by HIV-1 and Other Primate Lentiviruses
Johan A. den Boon, Arturo Diaz, Paul Ahlquist. Many viruses that replicate in the cytoplasm compartmentalize their genome replication and transcription in organelle-like structures that enhance replication efficiency and protection from host d…. . . . → Read More: Cytoplasmic Viral Replication Complexes
Joseph Heitman. Sexual reproduction enables eukaryotic organisms to reassort genetic diversity and purge deleterious mutations, producing better-fit progeny. Sex arose early and pervades eukaryotes. Fungal and pa…. . . . → Read More: Evolution of Eukaryotic Microbial Pathogens via Covert Sexual Reproduction
Samuel H. Speck, Don Ganem. Latency is a state of cryptic viral infection associated with genomic persistence and highly restricted gene expression. Its hallmark is reversibility: under appropriate circumstances, expression …. . . . → Read More: Viral Latency and Its Regulation: Lessons from the ?-Herpesviruses
Kai Papenfort, Jörg Vogel. Bacteria constitute a large and diverse class of infectious agents, causing devastating diseases in humans, animals, and plants. Our understanding of gene expression control, which forms the basis…. . . . → Read More: Regulatory RNA in Bacterial Pathogens
Andrea J. Jani, Peggy A. Cotter. Type VI secretion systems (T6SS) have been studied primarily in the context of pathogenic bacteria-host interactions. Recent data suggest, however, that these versatile secretion systems may also …. . . . → Read More: Type VI Secretion: Not Just for Pathogenesis Anymore
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CELL HOST . . . → Read More: A Place to Call Home