Lucia Peixoto, Feng Chen, Omar S. Harb, Paul H. Davis, Daniel P. Beiting, Catie Small Brownback, Dinkorma Ouloguem, David S. Roos. Apicomplexan parasites release factors via specialized secretory organelles (rhoptries, micronemes) that are thought to c… . . . → Read More: Integrative Genomic Approaches Highlight a Family of Parasite-Specific Kinases that Regulate Host Responses
Shahab Shahnazari, Wei-Lien Yen, Cheryl L. Birmingham, Jessica Shiu, Anton Namolovan, Yiyu T. Zheng, Keiko Nakayama, Daniel J. Klionsky, John H. Brumell. Autophagy mediates the degradation of cytoplasmic contents in the lysosome and plays a significant… . . . → Read More: A Diacylglycerol-Dependent Signaling Pathway Contributes to Regulation of Antibacterial Autophagy
Kevin J. Sokoloski, Alexa M. Dickson, Emily L. Chaskey, Nicole L. Garneau, Carol J. Wilusz, Jeffrey Wilusz. How viral transcripts are protected from the cellular RNA decay machinery and the importance of this protection for the virus are largely unknow… . . . → Read More: Sindbis Virus Usurps the Cellular HuR Protein to Stabilize Its Transcripts and Promote Productive Infections in Mammalian and Mosquito Cells
Anja Fuchs, Tsai-Yu Lin, David W. Beasley, Cordula M. Stover, Wilhelm J. Schwaeble, Theodore C. Pierson, Michael S. Diamond. An intact complement system is crucial for limiting West Nile virus (WNV) dissemination. Herein, we define how complement direc… . . . → Read More: Direct Complement Restriction of Flavivirus Infection Requires Glycan Recognition by Mannose-Binding Lectin
William E. O’Gorman, Padma Sampath, Erin F. Simonds, Rachel Sikorski, Mark O’Malley, Peter O. Krutzik, Hannah Chen, Vijay Panchanathan, Geeta Chaudhri, Gunasegaran Karupiah, David B. Lewis, Steve H. Thorne, Garry P. Nolan. Vaccinia immunization was piv… . . . → Read More: Alternate Mechanisms of Initial Pattern Recognition Drive Differential Immune Responses to Related Poxviruses
Meredith M. Curtis, Emily Rowell, Shahin Shafiani, Amina Negash, Kevin B. Urdahl, Christopher B. Wilson, Sing Sing Way. The degree of lineage stability achieved by pathogen-specific CD4+ T cells in vivo, and how this impacts host defense against infe… . . . → Read More: Fidelity of Pathogen-Specific CD4+ T Cells to the Th1 Lineage Is Controlled by Exogenous Cytokines, Interferon-? Expression, and Pathogen Lifestyle
Sukumar Saha, Xuefang Jing, Shin Yong Park, Shiyong Wang, Xinna Li, Dipika Gupta, Roman Dziarski. There are multiple mechanisms that protect the intestine from an excessive inflammatory response to intestinal microorganisms. We report here that all fou… . . . → Read More: Peptidoglycan Recognition Proteins Protect Mice from Experimental Colitis by Promoting Normal Gut Flora and Preventing Induction of Interferon-?
Lionel B. Ivashkiv. In this issue of Cell Host & Microbe, O’Gorman et al. (2010) identify a key role for early TLR2-mediated IL-6 production and STAT3 activation in generating protective immunity against p…. . . . → Read More: STAT Activation during Viral Infection In Vivo: Where’s the Interferon?
Stephen Rubino, Jooeun Lee, Stephen E. Girardin. Peptidoglycan recognition proteins (PGRPs or Pglyrps) regulate antibacterial responses in Drosophila, yet their functions in humans remain unclear. In this issue of Cell Host & Micro…. . . . → Read More: Mammalian PGRPs Also Mind the Fort
Frank Lafont. Autophagy can orchestrate innate immune responses to bacterial infection by targeting invading pathogens for lysosomal degradation. In this issue of Cell Host & Microbe, Shahnazari et a…. . . . → Read More: Autophagy Employs a New DAGger against Bacteria