In Vivo Mechanisms of Vaccine-Induced Protection against HPV Infection

Patricia M. Day, Rhonda C. Kines, Cynthia D. Thompson, Subhashini Jagu, Richard B. Roden, Douglas R. Lowy, John T. Schiller. Using a human papillomavirus (HPV) cervicovaginal murine challenge model, we microscopically examined the in vivo mechanisms o… . . . → Read More: In Vivo Mechanisms of Vaccine-Induced Protection against HPV Infection

Enterobacteriaceae Act in Concert with the Gut Microbiota to Induce Spontaneous and Maternally Transmitted Colitis

Wendy S. Garrett, Carey A. Gallini, Tanya Yatsunenko, Monia Michaud, Andrea DuBois, Mary L. Delaney, Shivesh Punit, Maria Karlsson, Lynn Bry, Jonathan N. Glickman, Jeffrey I. Gordon, Andrew B. Onderdonk, Laurie H. Glimcher. Disruption of homeostasis be… . . . → Read More: Enterobacteriaceae Act in Concert with the Gut Microbiota to Induce Spontaneous and Maternally Transmitted Colitis

The Human Immune Response to Dengue Virus Is Dominated by Highly Cross-Reactive Antibodies Endowed with Neutralizing and Enhancing Activity

Martina Beltramello, Katherine L. Williams, Cameron P. Simmons, Annalisa Macagno, Luca Simonelli, Nguyen Than Ha Quyen, Soila Sukupolvi-Petty, Erika Navarro-Sanchez, Paul R. Young, Aravinda M. de Silva, Félix A. Rey, Luca Varani, Stephen S. Whitehea… . . . → Read More: The Human Immune Response to Dengue Virus Is Dominated by Highly Cross-Reactive Antibodies Endowed with Neutralizing and Enhancing Activity

Cellular Networks Involved in the Influenza Virus Life Cycle

Tokiko Watanabe, Shinji Watanabe, Yoshihiro Kawaoka. Influenza viruses cause epidemics and pandemics. Like all viruses, influenza viruses rely on the host cellular machinery to support their life cycle. Accordingly, identification of the host functi…. . . . → Read More: Cellular Networks Involved in the Influenza Virus Life Cycle

The Cell Biology of HIV-1 Virion Genesis

Paul D. Bieniasz. Recent work has illuminated three critical aspects of the cell biology of HIV-1 particle genesis. First, we have come to understand which cellular membranes are selected as platforms for virus par…. . . . → Read More: The Cell Biology of HIV-1 Virion Genesis

A Type VI Secretion System of Pseudomonas aeruginosa Targets a Toxin to Bacteria

Rachel D. Hood, Pragya Singh, FoSheng Hsu, Tüzün Güvener, Mike A. Carl, Rex R.S. Trinidad, Julie M. Silverman, Brooks B. Ohlson, Kevin G. Hicks, Rachael L. Plemel, Mo Li, Sandra Schwarz, Wenzhuo Y. Wang, Alexey J. Merz, David R. Goodlett, Joseph D. … . . . → Read More: A Type VI Secretion System of Pseudomonas aeruginosa Targets a Toxin to Bacteria

Influenza Virus Evolution, Host Adaptation, and Pandemic Formation

Jeffery K. Taubenberger, John C. Kash. Newly emerging or “re-emerging” viral diseases continue to pose significant global public health threats. Prototypic are influenza viruses that are major causes of human respiratory infections and…. . . . → Read More: Influenza Virus Evolution, Host Adaptation, and Pandemic Formation

A Biphasic Innate Immune MAPK Response Discriminates between the Yeast and Hyphal Forms of Candida albicans in Epithelial Cells

David L. Moyes, Manohursingh Runglall, Celia Murciano, Chengguo Shen, Deepa Nayar, Selvam Thavaraj, Arinder Kohli, Ayesha Islam, Hector Mora-Montes, Stephen J. Challacombe, Julian R. Naglik. Discriminating between commensal and pathogenic states of opp… . . . → Read More: A Biphasic Innate Immune MAPK Response Discriminates between the Yeast and Hyphal Forms of Candida albicans in Epithelial Cells

Structural and Functional Analysis of Prehistoric Lentiviruses Uncovers an Ancient Molecular Interface

David C. Goldstone, Melvyn W. Yap, Laura E. Robertson, Lesley F. Haire, William R. Taylor, Aris Katzourakis, Jonathan P. Stoye, Ian A. Taylor. Lentiviruses are widespread in a variety of vertebrates, often associated with chronic disease states. Howeve… . . . → Read More: Structural and Functional Analysis of Prehistoric Lentiviruses Uncovers an Ancient Molecular Interface