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By Mital J, Miller NJ, Fischer ER, Hackstadt T, on August 19th, 2010
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Specific chlamydial inclusion membrane proteins associate with active Src family kinases in microdomains that interact with the host microtubule network.
Cell Microbiol. 2010 Sep 1;12(9):1235-49
Authors: Mit… . . . → Read More: Specific chlamydial inclusion membrane proteins associate with active Src family kinases in microdomains that interact with the host microtubule network.
By Pedra JH, Narasimhan S, RendiÄ? D, Deponte K, Bell-Sakyi L, Wilson IB, Fikrig E, on August 19th, 2010
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Fucosylation enhances colonization of ticks by Anaplasma phagocytophilum.
Cell Microbiol. 2010 Sep 1;12(9):1222-34
Authors: Pedra JH, Narasimhan S, RendiÄ? D, Deponte K, Bell-Sakyi L, Wilson IB, Fikrig E
… . . . → Read More: Fucosylation enhances colonization of ticks by Anaplasma phagocytophilum.
By Dean P, Mühlen S, Quitard S, Kenny B, on August 19th, 2010
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The bacterial effectors EspG and EspG2 induce a destructive calpain activity that is kept in check by the co-delivered Tir effector.
Cell Microbiol. 2010 Sep 1;12(9):1308-21
Authors: Dean P, Mühlen S, Qui… . . . → Read More: The bacterial effectors EspG and EspG2 induce a destructive calpain activity that is kept in check by the co-delivered Tir effector.
By Huang B, Hubber A, McDonough JA, Roy CR, Scidmore MA, Carlyon JA, on August 19th, 2010
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The Anaplasma phagocytophilum-occupied vacuole selectively recruits Rab-GTPases that are predominantly associated with recycling endosomes.
Cell Microbiol. 2010 Sep 1;12(9):1292-307
Authors: Huang B, Hubber … . . . → Read More: The Anaplasma phagocytophilum-occupied vacuole selectively recruits Rab-GTPases that are predominantly associated with recycling endosomes.
By Lomma M, Dervins-Ravault D, Rolando M, Nora T, Newton HJ, Sansom FM, Sahr T, Gomez-Valero L, Jules M, Hartland EL, Buchrieser C, on August 19th, 2010
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The Legionella pneumophila F-box protein Lpp2082 (AnkB) modulates ubiquitination of the host protein parvin B and promotes intracellular replication.
Cell Microbiol. 2010 Sep 1;12(9):1272-91
Authors: Lomma M… . . . → Read More: The Legionella pneumophila F-box protein Lpp2082 (AnkB) modulates ubiquitination of the host protein parvin B and promotes intracellular replication.
By Kum WW, Lo BC, Deng W, Ziltener HJ, Finlay BB, on August 19th, 2010
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Impaired innate immune response and enhanced pathology during Citrobacter rodentium infection in mice lacking functional P-selectin.
Cell Microbiol. 2010 Sep 1;12(9):1250-71
Authors: Kum WW, Lo BC, Deng W, Z… . . . → Read More: Impaired innate immune response and enhanced pathology during Citrobacter rodentium infection in mice lacking functional P-selectin.
By Shames SR, Deng W, Guttman JA, de Hoog CL, Li Y, Hardwidge PR, Sham HP, Vallance BA, Foster LJ, Finlay BB, on August 19th, 2010
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The pathogenic E. coli type III effector EspZ interacts with host CD98 and facilitates host cell prosurvival signalling.
Cell Microbiol. 2010 Sep 1;12(9):1322-39
Authors: Shames SR, Deng W, Guttman JA, de Ho… . . . → Read More: The pathogenic E. coli type III effector EspZ interacts with host CD98 and facilitates host cell prosurvival signalling.
By Braun V, Wong A, Landekic M, Hong WJ, Grinstein S, Brumell JH, on August 19th, 2010
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Sorting nexin 3 (SNX3) is a component of a tubular endosomal network induced by Salmonella and involved in maturation of the Salmonella-containing vacuole.
Cell Microbiol. 2010 Sep 1;12(9):1352-67
Authors: B… . . . → Read More: Sorting nexin 3 (SNX3) is a component of a tubular endosomal network induced by Salmonella and involved in maturation of the Salmonella-containing vacuole.
By Böhme L, Albrecht M, Riede O, Rudel T, on August 19th, 2010
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Chlamydia trachomatis-infected host cells resist dsRNA-induced apoptosis.
Cell Microbiol. 2010 Sep 1;12(9):1340-51
Authors: Böhme L, Albrecht M, Riede O, Rudel T
Human pathogenic Chlamydia trachom… . . . → Read More: Chlamydia trachomatis-infected host cells resist dsRNA-induced apoptosis.
By Wallden K, Rivera-Calzada A, Waksman G, on August 19th, 2010
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Type IV secretion systems: versatility and diversity in function.
Cell Microbiol. 2010 Sep 1;12(9):1203-12
Authors: Wallden K, Rivera-Calzada A, Waksman G
Type IV secretion systems (T4SSs) are large … . . . → Read More: Type IV secretion systems: versatility and diversity in function.
By de Jong MF, Rolán HG, Tsolis RM, on August 19th, 2010
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Innate immune encounters of the (Type) 4th kind: Brucella.
Cell Microbiol. 2010 Sep 1;12(9):1195-202
Authors: de Jong MF, Rolán HG, Tsolis RM
In humans, pathogenic Brucella species cause a febrile… . . . → Read More: Innate immune encounters of the (Type) 4th kind: Brucella.
By Rikihisa Y, Lin M, Niu H, on August 19th, 2010
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Type IV secretion in the obligatory intracellular bacterium Anaplasma phagocytophilum.
Cell Microbiol. 2010 Sep 1;12(9):1213-21
Authors: Rikihisa Y, Lin M, Niu H
Anaplasma phagocytophilum is an oblig… . . . → Read More: Type IV secretion in the obligatory intracellular bacterium Anaplasma phagocytophilum.
By Durand EA, Maldonado-Arocho FJ, Castillo C, Walsh RL, Mecsas J, on August 9th, 2010
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The presence of professional phagocytes dictates the number of host cells targeted for Yop translocation during infection.
Cell Microbiol. 2010 Aug;12(8):1064-82
Authors: Durand EA, Maldonado-Arocho FJ, Cast… . . . → Read More: The presence of professional phagocytes dictates the number of host cells targeted for Yop translocation during infection.
By Losick VP, Haenssler E, Moy MY, Isberg RR, on August 9th, 2010
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LnaB: a Legionella pneumophila activator of NF-kappaB.
Cell Microbiol. 2010 Aug;12(8):1083-97
Authors: Losick VP, Haenssler E, Moy MY, Isberg RR
Legionella pneumophila possesses a large arsenal of ty… . . . → Read More: LnaB: a Legionella pneumophila activator of NF-kappaB.
By Su Y, Qiao W, Guo T, Tan J, Li Z, Chen Y, Li X, Li Y, Zhou J, Chen Q, on August 9th, 2010
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Microtubule-dependent retrograde transport of bovine immunodeficiency virus.
Cell Microbiol. 2010 Aug;12(8):1098-107
Authors: Su Y, Qiao W, Guo T, Tan J, Li Z, Chen Y, Li X, Li Y, Zhou J, Chen Q
Micr… . . . → Read More: Microtubule-dependent retrograde transport of bovine immunodeficiency virus.
By Moreau K, Lacas-Gervais S, Fujita N, Sebbane F, Yoshimori T, Simonet M, Lafont F, on August 9th, 2010
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Autophagosomes can support Yersinia pseudotuberculosis replication in macrophages.
Cell Microbiol. 2010 Aug;12(8):1108-23
Authors: Moreau K, Lacas-Gervais S, Fujita N, Sebbane F, Yoshimori T, Simonet M, Lafo… . . . → Read More: Autophagosomes can support Yersinia pseudotuberculosis replication in macrophages.
By Bussière FI, Michel V, Mémet S, Avé P, Vivas JR, Huerre M, Touati E, on August 9th, 2010
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H. pylori-induced promoter hypermethylation downregulates USF1 and USF2 transcription factor gene expression.
Cell Microbiol. 2010 Aug;12(8):1124-33
Authors: Bussière FI, Michel V, Mémet S, Avé P, V… . . . → Read More: H. pylori-induced promoter hypermethylation downregulates USF1 and USF2 transcription factor gene expression.
By Mishra BB, Moura-Alves P, Sonawane A, Hacohen N, Griffiths G, Moita LF, Anes E, on August 9th, 2010
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Mycobacterium tuberculosis protein ESAT-6 is a potent activator of the NLRP3/ASC inflammasome.
Cell Microbiol. 2010 Aug;12(8):1046-63
Authors: Mishra BB, Moura-Alves P, Sonawane A, Hacohen N, Griffiths G, Mo… . . . → Read More: Mycobacterium tuberculosis protein ESAT-6 is a potent activator of the NLRP3/ASC inflammasome.
By Heiniger RW, Winther-Larsen HC, Pickles RJ, Koomey M, Wolfgang MC, on August 9th, 2010
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Infection of human mucosal tissue by Pseudomonas aeruginosa requires sequential and mutually dependent virulence factors and a novel pilus-associated adhesin.
Cell Microbiol. 2010 Aug;12(8):1158-73
Authors: … . . . → Read More: Infection of human mucosal tissue by Pseudomonas aeruginosa requires sequential and mutually dependent virulence factors and a novel pilus-associated adhesin.
By Preuss I, Hildebrand D, Orth JH, Aktories K, Kubatzky KF, on August 9th, 2010
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Pasteurella multocida toxin is a potent activator of anti-apoptotic signalling pathways.
Cell Microbiol. 2010 Aug;12(8):1174-85
Authors: Preuss I, Hildebrand D, Orth JH, Aktories K, Kubatzky KF
Toxig… . . . → Read More: Pasteurella multocida toxin is a potent activator of anti-apoptotic signalling pathways.
By Butler RE, Cihlarova V, Stewart GR, on August 9th, 2010
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Effective generation of reactive oxygen species in the mycobacterial phagosome requires K+ efflux from the bacterium.
Cell Microbiol. 2010 Aug;12(8):1186-93
Authors: Butler RE, Cihlarova V, Stewart GR
… . . . → Read More: Effective generation of reactive oxygen species in the mycobacterial phagosome requires K+ efflux from the bacterium.
By Eilers B, Mayer-Scholl A, Walker T, Tang C, Weinrauch Y, Zychlinsky A, on August 9th, 2010
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Neutrophil antimicrobial proteins enhance Shigella flexneri adhesion and invasion.
Cell Microbiol. 2010 Aug;12(8):1134-43
Authors: Eilers B, Mayer-Scholl A, Walker T, Tang C, Weinrauch Y, Zychlinsky A
… . . . → Read More: Neutrophil antimicrobial proteins enhance Shigella flexneri adhesion and invasion.
By Madan V, Redondo N, Carrasco L, on August 9th, 2010
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Cell permeabilization by poliovirus 2B viroporin triggers bystander permeabilization in neighbouring cells through a mechanism involving gap junctions.
Cell Microbiol. 2010 Aug;12(8):1144-57
Authors: Madan V… . . . → Read More: Cell permeabilization by poliovirus 2B viroporin triggers bystander permeabilization in neighbouring cells through a mechanism involving gap junctions.
By Jo EK, on August 9th, 2010
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Innate immunity to mycobacteria: vitamin D and autophagy.
Cell Microbiol. 2010 Aug;12(8):1026-35
Authors: Jo EK
Autophagy is an ancient mechanism of protein degradation and a novel antimicrobial stra… . . . → Read More: Innate immunity to mycobacteria: vitamin D and autophagy.
By Silver KL, Higgins SJ, McDonald CR, Kain KC, on August 9th, 2010
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Complement driven innate immune response to malaria: fuelling severe malarial diseases.
Cell Microbiol. 2010 Aug;12(8):1036-45
Authors: Silver KL, Higgins SJ, McDonald CR, Kain KC
Severe malaria rema… . . . → Read More: Complement driven innate immune response to malaria: fuelling severe malarial diseases.
By Park CJ, Han SW, Chen X, Ronald PC, on August 9th, 2010
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Elucidation of XA21-mediated innate immunity.
Cell Microbiol. 2010 Aug;12(8):1017-25
Authors: Park CJ, Han SW, Chen X, Ronald PC
In the early 1970s, the Xa21 gene from the wild rice species Oryza lon… . . . → Read More: Elucidation of XA21-mediated innate immunity.
By Weflen AW, Alto NM, Viswanathan VK, Hecht G, on August 3rd, 2010
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E. coli secreted protein F promotes EPEC invasion of intestinal epithelial cells via an SNX9-dependent mechanism.
Cell Microbiol. 2010 Jul;12(7):919-29
Authors: Weflen AW, Alto NM, Viswanathan VK, Hecht G
… . . . → Read More: E. coli secreted protein F promotes EPEC invasion of intestinal epithelial cells via an SNX9-dependent mechanism.
By Aly AS, Downie MJ, Mamoun CB, Kappe SH, on August 3rd, 2010
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Subpatent infection with nucleoside transporter 1-deficient Plasmodium blood stage parasites confers sterile protection against lethal malaria in mice.
Cell Microbiol. 2010 Jul;12(7):930-8
Authors: Aly AS, D… . . . → Read More: Subpatent infection with nucleoside transporter 1-deficient Plasmodium blood stage parasites confers sterile protection against lethal malaria in mice.
By Rolando M, Stefani C, Flatau G, Auberger P, Mettouchi A, Mhlanga M, Rapp U, Galmiche A, Lemichez E, on August 3rd, 2010
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Transcriptome dysregulation by anthrax lethal toxin plays a key role in induction of human endothelial cell cytotoxicity.
Cell Microbiol. 2010 Jul;12(7):891-905
Authors: Rolando M, Stefani C, Flatau G, Auber… . . . → Read More: Transcriptome dysregulation by anthrax lethal toxin plays a key role in induction of human endothelial cell cytotoxicity.
By Secundino N, Kimblin N, Peters NC, Lawyer P, Capul AA, Beverley SM, Turco SJ, Sacks D, on August 3rd, 2010
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Proteophosphoglycan confers resistance of Leishmania major to midgut digestive enzymes induced by blood feeding in vector sand flies.
Cell Microbiol. 2010 Jul;12(7):906-18
Authors: Secundino N, Kimblin N, Pe… . . . → Read More: Proteophosphoglycan confers resistance of Leishmania major to midgut digestive enzymes induced by blood feeding in vector sand flies.
By Kisiela DI, Aulik NA, Atapattu DN, Czuprynski CJ, on August 3rd, 2010
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N-terminal region of Mannheimia haemolytica leukotoxin serves as a mitochondrial targeting signal in mammalian cells.
Cell Microbiol. 2010 Jul;12(7):976-87
Authors: Kisiela DI, Aulik NA, Atapattu DN, Czupryn… . . . → Read More: N-terminal region of Mannheimia haemolytica leukotoxin serves as a mitochondrial targeting signal in mammalian cells.
By Khaminets A, Hunn JP, Könen-Waisman S, Zhao YO, Preukschat D, Coers J, Boyle JP, Ong YC, Boothroyd JC, Reichmann G, Howard JC, on August 3rd, 2010
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Coordinated loading of IRG resistance GTPases on to the Toxoplasma gondii parasitophorous vacuole.
Cell Microbiol. 2010 Jul;12(7):939-61
Authors: Khaminets A, Hunn JP, Könen-Waisman S, Zhao YO, Preukscha… . . . → Read More: Coordinated loading of IRG resistance GTPases on to the Toxoplasma gondii parasitophorous vacuole.
By Wittkop L, Schwarz A, Cassany A, Grün-Bernhard S, Delaleau M, Rabe B, Cazenave C, Gerlich W, Glebe D, Kann M, on August 3rd, 2010
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Inhibition of protein kinase C phosphorylation of hepatitis B virus capsids inhibits virion formation and causes intracellular capsid accumulation.
Cell Microbiol. 2010 Jul;12(7):962-75
Authors: Wittkop L, S… . . . → Read More: Inhibition of protein kinase C phosphorylation of hepatitis B virus capsids inhibits virion formation and causes intracellular capsid accumulation.
By Dam S, Lohia A, on August 3rd, 2010
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Entamoeba histolytica sirtuin EhSir2a deacetylates tubulin and regulates the number of microtubular assemblies during the cell cycle.
Cell Microbiol. 2010 Jul;12(7):1002-14
Authors: Dam S, Lohia A
We… . . . → Read More: Entamoeba histolytica sirtuin EhSir2a deacetylates tubulin and regulates the number of microtubular assemblies during the cell cycle.
By Schmolke M, GarcÃa-Sastre A, on August 3rd, 2010
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Evasion of innate and adaptive immune responses by influenza A virus.
Cell Microbiol. 2010 Jul;12(7):873-80
Authors: Schmolke M, GarcÃa-Sastre A
Host organisms have developed sophisticated antivir… . . . → Read More: Evasion of innate and adaptive immune responses by influenza A virus.
By Songsungthong W, Higgins MC, Rolán HG, Murphy JL, Mecsas J, on August 3rd, 2010
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ROS-inhibitory activity of YopE is required for full virulence of Yersinia in mice.
Cell Microbiol. 2010 Jul;12(7):988-1001
Authors: Songsungthong W, Higgins MC, Rolán HG, Murphy JL, Mecsas J
YopE… . . . → Read More: ROS-inhibitory activity of YopE is required for full virulence of Yersinia in mice.
By Monroe KM, McWhirter SM, Vance RE, on August 3rd, 2010
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Induction of type I interferons by bacteria.
Cell Microbiol. 2010 Jul;12(7):881-90
Authors: Monroe KM, McWhirter SM, Vance RE
Type I interferons (IFNs) are secreted cytokines that orchestrate diverse… . . . → Read More: Induction of type I interferons by bacteria.
By Latgé JP, on August 3rd, 2010
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Tasting the fungal cell wall.
Cell Microbiol. 2010 Jul;12(7):863-72
Authors: Latgé JP
The search for common host mechanisms that recognize human fungal pathogens as non-self has led to an increase… . . . → Read More: Tasting the fungal cell wall.
By Oliva R, Win J, Raffaele S, Boutemy L, Bozkurt TO, Chaparro-Garcia A, Segretin ME, Stam R, Schornack S, Cano LM, van Damme M, Huitema E, Thines M, Banfield MJ, Kamoun S, on August 3rd, 2010
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Recent developments in effector biology of filamentous plant pathogens.
Cell Microbiol. 2010 Jul;12(7):1015
Authors: Oliva R, Win J, Raffaele S, Boutemy L, Bozkurt TO, Chaparro-Garcia A, Segretin ME, Stam R,… . . . → Read More: Recent developments in effector biology of filamentous plant pathogens.
By Eugénie Bassères, Giuseppe Coppotelli, Thorsten Pfirrmann, Jens B. Andersen, Maria Masucci, Teresa Frisan, on June 30th, 2010
Invasion of eukaryotic target cells by pathogenic bacteria requires extensive remodelling of the membrane and actin cytoskeleton. Here we show that the remodelling process is regulated by the ubiquitin C-terminal hydrolase UCH-L1 that promotes the inva… . . . → Read More: The ubiquitin C-terminal hydrolase UCH-L1 promotes bacterial invasion by altering the dynamics of the actin cytoskeleton
By Dong-Min Shin, Jae-Min Yuk, Hye-Mi Lee, Sang-Hee Lee, Ji Woong Son, Clifford V. Harding, Jin-Man Kim, Robert L. Modlin, Eun-Kyeong Jo, on June 18th, 2010
In human monocytes, Toll-like receptor (TLR) 2/1 activation leads to vitamin D3-dependent antimycobacterial activities, but the molecular mechanisms by which TLR2/1 stimulation induces antimicrobial activities against mycobacteria remain unclear. Here … . . . → Read More: Mycobacterial lipoprotein activates autophagy via TLR2/1/CD14 and a functional vitamin D receptor signalling
By Vijay R. Gupta, Brenda A. Wilson, Steven R. Blanke, on June 10th, 2010
Plasma membrane sphingomyelin (SM) binds the Helicobacter pylori vacuolating toxin (VacA) to the surface of epithelial cells. To evaluate the importance of SM for VacA cellular entry, we characterized toxin uptake and trafficking within cells enriched … . . . → Read More: Sphingomyelin is important for the cellular entry and intracellular localization of Helicobacter pylori VacA
By Anirban Banerjee, Nina M. van Sorge, Tamsin R. Sheen, Satoshi Uchiyama, Tim J. Mitchell, Kelly S. Doran, on May 25th, 2010
Streptococcus pneumoniae (SPN), the leading cause of meningitis in children and adults worldwide, is associated with an overwhelming host inflammatory response and subsequent brain injury. Here we examine the global response of the blood[ndash]brain ba… . . . → Read More: Activation of brain endothelium by pneumococcal neuraminidase NanA promotes bacterial internalization
By Jovanka Bestebroer, Piet C. Aerts, Suzan H. M. Rooijakkers, Manoj K. Pandey, Jörg Köhl, Jos A. G. van Strijp, Carla J. C. de Haas, on May 25th, 2010
The human pathogen Staphylococcus aureus has a plethora of virulence factors that promote its colonization and survival in the host. Among such immune modulators are staphylococcal superantigen-like (SSL) proteins, comprising a family of 14 small, secr… . . . → Read More: Functional basis for complement evasion by staphylococcal superantigen-like 7
By George A. Belov, Gennadiy Kovtunovych, Catherine L. Jackson, Ellie Ehrenfeld, on May 20th, 2010
Viruses are intracellular parasites whose reproduction relies on factors provided by the host. The cellular protein GBF1 is critical for poliovirus replication. Here we show that the contribution of GBF1 to virus replication is different from its known… . . . → Read More: Poliovirus replication requires the N-terminus but not the catalytic Sec7 domain of ArfGEF GBF1
By Blaise Ndjamen, Byung-Ho Kang, Kiyotaka Hatsuzawa, Peter E. Kima, on May 20th, 2010
Macrophages that express representative endoplasmic reticulum (ER) molecules tagged with green fluorescence protein were generated to assess the recruitment of ER molecules to Leishmania parasitophorous vacuoles (PVs). More than 90% of PVs harbouring L… . . . → Read More: Leishmania parasitophorous vacuoles interact continuously with the host cell’s endoplasmic reticulum; parasitophorous vacuoles are hybrid compartments
By Guntram A. Grassl, Marco Faustmann, Navkiran Gill, Lori Zbytnuik, Helen Merkens, Leslie So, Fabio M. Rossi, Kelly M. McNagny, B. Brett Finlay, on May 18th, 2010
CD34 is a highly glycosylated sialomucin expressed on a variety of cells, ranging from vascular endothelial cells to haematopoietic stem cells. Depending on its glycosylation state, CD34 has been shown to promote or inhibit cell adhesion and migration;… . . . → Read More: CD34 mediates intestinal inflammation in Salmonella-infected mice
By Çagla Tükel, Jessalyn H. Nishimori, R. Paul Wilson, Maria G. Winter, A. Marijke Keestra, Jos P. M. van Putten, Andreas J. Bäumler, on May 18th, 2010
Responses to host amyloids and curli amyloid fibrils of Escherichia coli and Salmonella enterica serotype Typhimurium are mediated through Toll-like receptor (TLR) 2. Here we show that TLR2 alone was not sufficient for mediating responses to curli. Ins… . . . → Read More: Toll-like receptors 1 and 2 cooperatively mediate immune responses to curli, a common amyloid from enterobacterial biofilms
By Simone Külzer, Melanie Rug, Klaus Brinkmann, Ping Cannon, Alan Cowman, Klaus Lingelbach, Gregory L. Blatch, Alexander G. Maier, Jude M. Przyborski, on May 6th, 2010
Plasmodium falciparum is predicted to transport over 300 proteins to the cytosol of its chosen host cell, the mature human erythrocyte, including 19 members of the Hsp40 family. Here, we have generated transfectant lines expressing GFP- or HA-Strep-tag… . . . → Read More: Parasite-encoded Hsp40 proteins define novel mobile structures in the cytosol of the P. falciparum-infected erythrocyte
By Virginie Braun, Anthony Wong, Marija Landekic, Wan Jin Hong, Sergio Grinstein, John H. Brumell, on May 6th, 2010
Salmonella enterica serovar Typhimurium is an intracellular pathogen that grows within a modified endomembrane compartment, the Salmonella-containing vacuole (SCV). Maturation of nascent SCVs involves the recruitment of early endosome markers and the r… . . . → Read More: Sorting nexin 3 (SNX3) is a component of a tubular endosomal network induced by Salmonella and involved in maturation of the Salmonella-containing vacuole
By Linda Böhme, Marco Albrecht, Oliver Riede, Thomas Rudel, on May 6th, 2010
Human pathogenic Chlamydia trachomatis have evolved sophisticated mechanisms to manipulate host cell signalling pathways in order to prevent apoptosis. We show here that host cells infected with C. trachomatis resist apoptosis induced by polyI:C, a syn… . . . → Read More: Chlamydia trachomatis-infected host cells resist dsRNA-induced apoptosis
By Veerubommu Shanmugam, Mordechai Ronen, Samer Shalaby, Olga Larkov, Yocheved Rachamim, Ruthi Hadar, Mark S. Rose, Shmuel Carmeli, Benjamin A. Horwitz, Sophie Lev, on April 27th, 2010
The transcription factor ChAP1 of the fungal pathogen of maize, Cochliobolus heterostrophus, responds to oxidative stress by migration to the nucleus and activation of antioxidant genes. Phenolic and related compounds found naturally in the host also t… . . . → Read More: The fungal pathogen Cochliobolus heterostrophus responds to maize phenolics: novel small molecule signals in a plant-fungal interaction
By Irene Zornetta, Lucia Brandi, Blythe Janowiak, Federica Dal Molin, Fiorella Tonello, R. John Collier, Cesare Montecucco, on April 23rd, 2010
To investigate the cell entry and intracellular trafficking of anthrax oedema factor (EF) and lethal factor (LF), they were C-terminally fused to the enhanced green fluorescent protein (EGFP) and monomeric Cherry (mCherry) fluorescent proteins. Both ch… . . . → Read More: Imaging the cell entry of the anthrax oedema and lethal toxins with fluorescent protein chimeras
By Martin Melcher, Rebecca A. Muhle, Philipp P. Henrich, Susan M. Kraemer, Marion Avril, Ines Vigan-Womas, Odile Mercereau-Puijalon, Joseph D. Smith, David A. Fidock, on April 21st, 2010
Transport of Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) variants to the red blood cell (RBC) surface enables malarial parasite evasion of host immunity by modifying the antigenic and adhesive properties of infected RBCs. In this stud… . . . → Read More: Identification of a role for the PfEMP1 semi-conserved head structure in protein trafficking to the surface of Plasmodium falciparum infected red blood cells
By Stephanie R. Shames, Wanyin Deng, Julian A. Guttman, Carmen L. de Hoog, Yuling Li, Philip R. Hardwidge, Ho Pan Sham, Bruce A. Vallance, Leonard J. Foster, B. Brett Finlay, on March 31st, 2010
Enterohaemorrhagic and enteropathogenic Escherichia coli (EHEC and EPEC respectively) are diarrhoeal pathogens that cause the formation of attaching and effacing (A/E) lesions on infected host cells. These pathogens encode a type III secretion system (… . . . → Read More: The pathogenic E. coli type III effector EspZ interacts with host CD98 and facilitates host cell prosurvival signalling
By Paul Dean, Sabrina Mühlen, Sabine Quitard, Brendan Kenny, on March 25th, 2010
Bacterial pathogens deliver multiple effector proteins into eukaryotic cells to subvert host cellular processes and an emerging theme is the cooperation between different effectors. Here, we reveal that a fine balance exists between effectors that are … . . . → Read More: The bacterial effectors EspG and EspG2 induce a destructive calpain activity that is kept in check by the co-delivered Tir effector
By Bernice Huang, Andree Hubber, Justin A. McDonough, Craig R. Roy, Marci A. Scidmore, Jason A. Carlyon, on March 25th, 2010
Anaplasma phagocytophilum is an obligate intracellular bacterium that infects neutrophils to reside within a host cell-derived vacuole. The A. phagocytophilum-occupied vacuole (ApV) fails to mature along the endocytic pathway and is non-fusogenic with … . . . → Read More: The Anaplasma phagocytophilum-occupied vacuole selectively recruits Rab-GTPases that are predominantly associated with recycling endosomes
By M. Lomma, D. Dervins-Ravault, M. Rolando, T. Nora, H. J. Newton, F. M. Samson, T. Sahr, L. Gomez-Valero, M. Jules, E. L. Hartland, C. Buchrieser, on March 25th, 2010
The environmental pathogen Legionella pneumophila encodes three proteins containing F-box domains and additional protein[ndash]protein interaction domains, reminiscent of eukaryotic SCF ubiquitin[ndash]protein ligases. Here we show that the F-box prote… . . . → Read More: The Legionella pneumophila F-box protein Lpp2082 (AnkB) modulates ubiquitination of the host protein parvin B and promotes intracellular replication
By Winnie W. S. Kum, Bernard C. Lo, Wanyin Deng, Hermann J. Ziltener, B. Brett Finlay, on March 25th, 2010
The selectin family of adhesion molecules mediates recruitment of immune cells to sites of inflammation which is critical for host resistance against infection. To characterize the role of selectins in host defence against Citrobacter rodentium infecti… . . . → Read More: Impaired innate immune response and enhanced pathology during Citrobacter rodentium infection in mice lacking functional P-selectin
By Jeffrey Mital, Natalie J. Miller, Elizabeth R. Fischer, Ted Hackstadt, on March 19th, 2010
Chlamydiae are Gram-negative obligate intracellular bacteria that cause diseases with significant medical and economic impact. Chlamydia trachomatis replicates within a vacuole termed an inclusion, which is extensively modified by the insertion of a nu… . . . → Read More: Specific chlamydial inclusion membrane proteins associate with active Src family kinases in microdomains that interact with the host microtubule network
By Joao H. F. Pedra, Sukanya Narasimhan, Dubravko Rendić, Kathleen DePonte, Lesley Bell-Sakyi, Iain B. H. Wilson, Erol Fikrig, on March 19th, 2010
Fucosylated structures participate in a wide range of pathological processes in eukaryotes and prokaryotes. The impact of fucose on microbial pathogenesis, however, has been less appreciated in arthropods of medical relevance. Thus, we used the tick-bo… . . . → Read More: Fucosylation enhances colonization of ticks by Anaplasma phagocytophilum
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