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By Liu WT, Yang YL, Xu Y, Lamsa A, Haste NM, Yang JY, Ng J, Gonzalez D, Ellermeier CD, Straight PD, Pevzner PA, Pogliano J, Nizet V, Pogliano K, Dorrestein PC, on September 22nd, 2010
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Imaging mass spectrometry of intraspecies metabolic exchange revealed the cannibalistic factors of Bacillus subtilis.
Proc Natl Acad Sci U S A. 2010 Sep 14;107(37):16286-90
Authors: Liu WT, Yang YL, Xu Y, L… . . . → Read More: Imaging mass spectrometry of intraspecies metabolic exchange revealed the cannibalistic factors of Bacillus subtilis.
By Callura JM, Dwyer DJ, Isaacs FJ, Cantor CR, Collins JJ, on September 22nd, 2010
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Tracking, tuning, and terminating microbial physiology using synthetic riboregulators.
Proc Natl Acad Sci U S A. 2010 Sep 7;107(36):15898-903
Authors: Callura JM, Dwyer DJ, Isaacs FJ, Cantor CR, Collins JJ… . . . → Read More: Tracking, tuning, and terminating microbial physiology using synthetic riboregulators.
By Wagner S, Stenta M, Metzger LC, Dal Peraro M, Cornelis GR, on August 14th, 2010
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Length control of the injectisome needle requires only one molecule of Yop secretion protein P (YscP).
Proc Natl Acad Sci U S A. 2010 Aug 3;107(31):13860-5
Authors: Wagner S, Stenta M, Metzger LC, Dal Peraro… . . . → Read More: Length control of the injectisome needle requires only one molecule of Yop secretion protein P (YscP).
By Zhang HP, Be'er A, Florin EL, Swinney HL, on August 14th, 2010
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Collective motion and density fluctuations in bacterial colonies.
Proc Natl Acad Sci U S A. 2010 Aug 3;107(31):13626-30
Authors: Zhang HP, Be’er A, Florin EL, Swinney HL
Flocking birds, fish schools,… . . . → Read More: Collective motion and density fluctuations in bacterial colonies.
By 3R-Microbiology, on August 8th, 2010
Ying Kong,
Hequan Yao,
Hongjun Ren,
Selvakumar Subbian,
Suat L. G. Cirillo,
James C. Sacchettini,
Jianghong Rao,
and Jeffrey D. Cirillo
See the paper
The slow growth rate and genetic intractability of tubercle bacilli has hindered progress toward understanding tuberculosis, one of the . . . → Read More: Imaging tuberculosis with endogenous ?-lactamase reporter enzyme fluorescence in live mice
By Kawli T, Wu C, Tan MW, on August 6th, 2010
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Systemic and cell intrinsic roles of Gq{alpha} signaling in the regulation of innate immunity, oxidative stress, and longevity in Caenorhabditis elegans.
Proc Natl Acad Sci U S A. 2010 Aug 3;107(31):13788-93
… . . . → Read More: Systemic and cell intrinsic roles of Gq{alpha} signaling in the regulation of innate immunity, oxidative stress, and longevity in Caenorhabditis elegans.
By Manson JM, Hancock LE, Gilmore MS, on August 3rd, 2010
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Mechanism of chromosomal transfer of Enterococcus faecalis pathogenicity island, capsule, antimicrobial resistance, and other traits.
Proc Natl Acad Sci U S A. 2010 Jul 6;107(27):12269-74
Authors: Manson J… . . . → Read More: Mechanism of chromosomal transfer of Enterococcus faecalis pathogenicity island, capsule, antimicrobial resistance, and other traits.
By Byun H, Halani N, Mertz JA, Ali AF, Lozano MM, Dudley JP, on August 3rd, 2010
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Retroviral Rem protein requires processing by signal peptidase and retrotranslocation for nuclear function.
Proc Natl Acad Sci U S A. 2010 Jul 6;107(27):12287-92
Authors: Byun H, Halani N, Mertz JA, Ali AF, … . . . → Read More: Retroviral Rem protein requires processing by signal peptidase and retrotranslocation for nuclear function.
By Wu HY, Brian DA, on August 3rd, 2010
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Subgenomic messenger RNA amplification in coronaviruses.
Proc Natl Acad Sci U S A. 2010 Jul 6;107(27):12257-62
Authors: Wu HY, Brian DA
Coronaviruses possess the largest known RNA genome, a 27- to … . . . → Read More: Subgenomic messenger RNA amplification in coronaviruses.
By Pham NL, Pewe LL, Fleenor CJ, Langlois RA, Legge KL, Badovinac VP, Harty JT, on August 3rd, 2010
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Exploiting cross-priming to generate protective CD8 T-cell immunity rapidly.
Proc Natl Acad Sci U S A. 2010 Jul 6;107(27):12198-203
Authors: Pham NL, Pewe LL, Fleenor CJ, Langlois RA, Legge KL, Badovinac VP,… . . . → Read More: Exploiting cross-priming to generate protective CD8 T-cell immunity rapidly.
By Leibler, S., Kussell, E., on August 3rd, 2010
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Individual histories and selection in heterogeneous populations.
Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):13183-8
Authors: Leibler S, Kussell E
The strength of selection in populations has trad… . . . → Read More: Individual histories and selection in heterogeneous populations.
By Meissner, F., Molawi, K., Zychlinsky, A., on August 3rd, 2010
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Mutant superoxide dismutase 1-induced IL-1beta accelerates ALS pathogenesis.
Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):13046-50
Authors: Meissner F, Molawi K, Zychlinsky A
ALS is a fatal motor ne… . . . → Read More: Mutant superoxide dismutase 1-induced IL-1beta accelerates ALS pathogenesis.
By Wu Y, Holding DR, Messing J, on August 3rd, 2010
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Gamma-zeins are essential for endosperm modification in quality protein maize.
Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):12810-5
Authors: Wu Y, Holding DR, Messing J
Essential amino acids like ly… . . . → Read More: Gamma-zeins are essential for endosperm modification in quality protein maize.
By Pruitt RN, Chambers MG, Ng KK, Ohi MD, Lacy DB, on August 3rd, 2010
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Structural organization of the functional domains of Clostridium difficile toxins A and B.
Proc Natl Acad Sci U S A. 2010 Jul 27;107(30):13467-72
Authors: Pruitt RN, Chambers MG, Ng KK, Ohi MD, Lacy DB
… . . . → Read More: Structural organization of the functional domains of Clostridium difficile toxins A and B.
By Vergauwen B, Elegheert J, Dansercoer A, Devreese B, Savvides SN, on August 3rd, 2010
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Glutathione import in Haemophilus influenzae Rd is primed by the periplasmic heme-binding protein HbpA.
Proc Natl Acad Sci U S A. 2010 Jul 27;107(30):13270-5
Authors: Vergauwen B, Elegheert J, Dansercoer A, … . . . → Read More: Glutathione import in Haemophilus influenzae Rd is primed by the periplasmic heme-binding protein HbpA.
By Wilke GA, Bubeck Wardenburg J, on August 3rd, 2010
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Role of a disintegrin and metalloprotease 10 in Staphylococcus aureus {alpha}-hemolysin-mediated cellular injury.
Proc Natl Acad Sci U S A. 2010 Jul 27;107(30):13473-8
Authors: Wilke GA, Bubeck Wardenburg J
… . . . → Read More: Role of a disintegrin and metalloprotease 10 in Staphylococcus aureus {alpha}-hemolysin-mediated cellular injury.
By Lázár-Molnár E, Chen B, Sweeney KA, Wang EJ, Liu W, Lin J, Porcelli SA, Almo SC, Nathenson SG, Jacobs WR, on August 3rd, 2010
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Programmed death-1 (PD-1)-deficient mice are extraordinarily sensitive to tuberculosis.
Proc Natl Acad Sci U S A. 2010 Jul 27;107(30):13402-7
Authors: Lázár-Molnár E, Chen B, Sweeney KA, Wang EJ, Li… . . . → Read More: Programmed death-1 (PD-1)-deficient mice are extraordinarily sensitive to tuberculosis.
By Duplantis BN, Osusky M, Schmerk CL, Ross DR, Bosio CM, Nano FE, on August 3rd, 2010
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Essential genes from Arctic bacteria used to construct stable, temperature-sensitive bacterial vaccines.
Proc Natl Acad Sci U S A. 2010 Jul 27;107(30):13456-60
Authors: Duplantis BN, Osusky M, Schmerk CL, R… . . . → Read More: Essential genes from Arctic bacteria used to construct stable, temperature-sensitive bacterial vaccines.
By 3R-Microbiology, on July 29th, 2010
See the paper
Sebastian Lücker,
Michael Wagner,
Frank Maixner,
Eric Pelletier,
Hanna Koch,
Benoit Vacherie,
Thomas Rattei,
Jaap S. Sinninghe Damsté,
Eva Spieck,
Denis Le Paslier,
and Holger Daims
Nitrospira are barely studied and mostly uncultured nitrite-oxidizing bacteria, which are, according to molecular data, among the most diverse and widespread nitrifiers in natural ecosystems and biological wastewater treatment. Here, environmental genomics was used to reconstruct the complete genome . . . → Read More: A Nitrospira metagenome illuminates the physiology and evolution of globally important nitrite-oxidizing bacteria
By 3R-Microbiology, on July 29th, 2010
See the paper
Georgia A. Wilke and
Juliane Bubeck Wardenburg
Staphylococcus aureus ?-hemolysin (Hla), a potent cytotoxin, plays an important role in the pathogenesis of staphylococcal diseases, including those caused by methicillin-resistant epidemic strains. Hla is secreted as a water-soluble monomer that undergoes a series of conformational changes to generate a heptameric, ?-barrel structure in host membranes. Structural . . . → Read More: Role of a disintegrin and metalloprotease 10 in Staphylococcus aureus ?-hemolysin–mediated cellular injury
By 3R-Microbiology, on July 29th, 2010
See the paper
Rory N. Pruitt,
Melissa G. Chambers,
Kenneth K.-S. Ng,
Melanie D. Ohi,
and D. Borden Lacy
Clostridium difficile toxins A and B are members of an important class of virulence factors known as large clostridial toxins (LCTs). Toxin action involves four major steps: receptor-mediated endocytosis, translocation of a catalytic glucosyltransferase domain across the membrane, release of the enzymatic moiety . . . → Read More: Structural organization of the functional domains of Clostridium difficile toxins A and B
By 3R-Microbiology, on July 29th, 2010
See the paper
Lucy C. Foulston and
Mervyn J. Bibb
Lantibiotics are ribosomally synthesized, posttranslationally modified peptide antibiotics. The biosynthetic gene cluster for microbisporicin, a potent lantibiotic produced by the actinomycete Microbispora corallina containing chlorinated tryptophan and dihydroxyproline residues, was identified by genome scanning and isolated from an M. corallina cosmid library. Heterologous expression in Nonomuraea sp. ATCC 39727 . . . → Read More: Microbisporicin gene cluster reveals unusual features of lantibiotic biosynthesis in actinomycetes
By 3R-Microbiology, on July 29th, 2010
See the paper
Barry N. Duplantis,
Milan Osusky,
Crystal L. Schmerk,
Darrell R. Ross,
Catharine M. Bosio,
and Francis E. Nano
All bacteria share a set of evolutionarily conserved essential genes that encode products that are required for viability. The great diversity of environments that bacteria inhabit, including environments at extreme temperatures, place adaptive pressure on essential genes. We sought to use this . . . → Read More: Essential genes from Arctic bacteria used to construct stable, temperature-sensitive bacterial vaccines
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