The Third Reviewer

Over 20 years ago an article in Biological Psychiatry described unusually high levels of dopamine in the thalamus of individuals with schizophrenia (). I had just started my graduate research work in the laboratory of Ralph Adams where this work was be… . . . → Read More: Dopamine in the Thalamus: A Hotbed for Psychosis?

Background: Schizophrenia and bipolar disorder are severe psychiatric diseases with overlapping symptomatology. Widespread brain morphologic abnormalities, including cortical thinning and subcortical volume reductions, have been demonstrated in schizop… . . . → Read More: Cortical Thickness and Subcortical Volumes in Schizophrenia and Bipolar Disorder

The N-methyl-D-aspartate receptor (NMDAR) hypofunction model of schizophrenia is based on the ability of NMDAR antagonists to produce many symptoms of the disease. Recent work in rats shows that NMDAR antagonist works synergistically with dopamine to p… . . . → Read More: A Thalamo-Hippocampal-Ventral Tegmental Area Loop May Produce the Positive Feedback that Underlies the Psychotic Break in Schizophrenia

Background: Schizophrenia is hypothesized to involve disordered connectivity between brain regions. Currently, there are no direct measures of brain connectivity; functional and structural connectivity used separately provide only limited insight. Simu… . . . → Read More: Brain Connectivity Is Not Only Lower but Different in Schizophrenia: A Combined Anatomical and Functional Approach

Background: Visual masking paradigms assess the early part of visual information processing, which may reflect vulnerability measures for schizophrenia. We examined the neural substrates of visual backward performance in unaffected sibling of schizophr… . . . → Read More: Regional Brain Activity During Early Visual Perception in Unaffected Siblings of Schizophrenia Patients

Background: While the neuroanatomical underpinnings of the functional brain disconnectivity observed in patients with schizophrenia (SZ) remain elusive, white matter fiber bundles of the brain are a likely candidate, given that they represent the infra… . . . → Read More: Corpus Callosum Abnormalities and Their Association with Psychotic Symptoms in Patients with Schizophrenia

Schizophrenia patients suffer from cognitive impairments that are not satisfactorily treated by currently available medications. Cognitive dysfunction in schizophrenia encompasses deficits in several cognitive modalities that can be differentially resp… . . . → Read More: Disruption of Performance in the Five-Choice Serial Reaction Time Task Induced By Administration of N-Methyl-D-Aspartate Receptor Antagonists: Relevance to Cognitive Dysfunction in Schizophrenia

Background: Increased immune sensitivity to gluten has been reported in schizophrenia. However, studies are inconsistent about this association.Methods: The sample of 471 individuals included 129 with recent-onset psychosis, 191 with multi-episode schi… . . . → Read More: Markers of Gluten Sensitivity and Celiac Disease in Recent-Onset Psychosis and Multi-Episode Schizophrenia

Background: Loss of cortical volume in frontotemporal regions has been reported in patients with schizophrenia and their relatives. Cortical area and thickness are determined by different genetic processes, and measuring these parameters separately may… . . . → Read More: Changes in the Frontotemporal Cortex and Cognitive Correlates in First-Episode Psychosis

Background: The combined analysis of several large genome-wide association studies identified the basic helix-loop-helix (bHLH) transcription factor TCF4 as one of the most significant schizophrenia susceptibility genes. Its function in the adult brain… . . . → Read More: Cognitive and Sensorimotor Gating Impairments in Transgenic Mice Overexpressing the Schizophrenia Susceptibility Gene Tcf4 in the Brain

Background: A recent genome-wide association study linked a common variant in RELN (rs7341475G) with risk for schizophrenia in women. In the largest neuroimaging intermediate phenotype study reported so far, we evaluated the effect of rs7341475 on an e… . . . → Read More: No Effect of a Common Allelic Variant in the Reelin Gene on Intermediate Phenotype Measures of Brain Structure, Brain Function, and Gene Expression

Background: Exposure to x-irradiation in early gestation has been shown to disrupt normal thalamocortical development in the monkey and thereby model one key feature of the neuropathology of schizophrenia. However, the effect of fetal irradiation on co… . . . → Read More: Fetal Irradiation Interferes with Adult Cognition in the Nonhuman Primate

Background: Spine density on the basilar dendrites of pyramidal neurons is lower in layer 3, but not in layers 5 and 6, in the dorsolateral prefrontal cortex (DLPFC) of subjects with schizophrenia. The expression of CDC42 (cell division cycle 42), a Rh… . . . → Read More: Altered Cortical CDC42 Signaling Pathways in Schizophrenia: Implications for Dendritic Spine Deficits

We would like to report a case of Capgras syndrome in a healthy subject that was induced by ketamine (an antagonist of the N-methyl-D-aspartate [NMDA] subtype of glutamate receptors). We believe this is the first report of delusion-like misidentificati… . . . → Read More: Capgras Syndrome Induced by Ketamine in a Healthy Subject

Background: To extend the early treatment response literature, this article aims to quantify the extent of heterogeneity and describe the characteristics of treatment response trajectories in schizophrenia.Methods: Data were extracted from two double-b… . . . → Read More: Elaboration on the Early-Onset Hypothesis of Antipsychotic Drug Action: Treatment Response Trajectories

Background: Movement abnormalities and cognitive deficits may represent external markers of an underlying neural process linked with the early etiology of psychosis. As basal ganglia function plays a governing role in both movement and cognitive proces… . . . → Read More: Markers of Basal Ganglia Dysfunction and Conversion to Psychosis: Neurocognitive Deficits and Dyskinesias in the Prodromal Period