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By thirdrev, on September 20th, 2010
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Ya-Hui Chou, Xiaoyan Zheng, Philip A. Beachy, Liqun Luo
We present evidence for a coupled two-step action of Hedgehog signaling in patterning axon targeting of Drosophila olfactory receptor neurons (ORNs). In the first step, differential Hedgehog pathway activity in peripheral sensory organ precursors creates ORN populations with different levels of the Patched receptor. Different Patched . . . → Read More: Patterning Axon Targeting of Olfactory Receptor Neurons by Coupled Hedgehog Signaling at Two Distinct Steps
By Gerdes K, Howard M, Szardenings F, on August 29th, 2010
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Pushing and pulling in prokaryotic DNA segregation.
Cell. 2010 Jun 11;141(6):927-42
Authors: Gerdes K, Howard M, Szardenings F
In prokaryotes, DNA can be segregated by three different types of cytosk… . . . → Read More: Pushing and pulling in prokaryotic DNA segregation.
By Sycuro LK, Pincus Z, Gutierrez KD, Biboy J, Stern CA, Vollmer W, Salama NR, on August 29th, 2010
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Peptidoglycan crosslinking relaxation promotes Helicobacter pylori’s helical shape and stomach colonization.
Cell. 2010 May 28;141(5):822-33
Authors: Sycuro LK, Pincus Z, Gutierrez KD, Biboy J, Stern CA, Vol… . . . → Read More: Peptidoglycan crosslinking relaxation promotes Helicobacter pylori’s helical shape and stomach colonization.
By Stechmann B, Bai SK, Gobbo E, Lopez R, Merer G, Pinchard S, Panigai L, Tenza D, Raposo G, Beaumelle B, Sauvaire D, Gillet D, Johannes L, Barbier J, on August 29th, 2010
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Inhibition of retrograde transport protects mice from lethal ricin challenge.
Cell. 2010 Apr 16;141(2):231-42
Authors: Stechmann B, Bai SK, Gobbo E, Lopez R, Merer G, Pinchard S, Panigai L, Tenza D, Raposo G… . . . → Read More: Inhibition of retrograde transport protects mice from lethal ricin challenge.
By Seaman MN, Peden AA, on August 29th, 2010
Ricin toxin hits a retrograde roadblock.
Cell. 2010 Apr 16;141(2):222-4
Authors: Seaman MN, Peden AA
To inhibit protein synthesis and induce cell death, plant ricin toxin and bacterial Shiga toxins enter the cell th… . . . → Read More: Ricin toxin hits a retrograde roadblock.
By Armitage JP, Berry RM, on August 29th, 2010
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Time for bacteria to slow down.
Cell. 2010 Apr 2;141(1):24-6
Authors: Armitage JP, Berry RM
The speed of the bacterial flagellar motor is thought to be regulated by structural changes in the motor. T… . . . → Read More: Time for bacteria to slow down.
By Boehm A, Kaiser M, Li H, Spangler C, Kasper CA, Ackermann M, Kaever V, Sourjik V, Roth V, Jenal U, on August 29th, 2010
Second messenger-mediated adjustment of bacterial swimming velocity.
Cell. 2010 Apr 2;141(1):107-16
Authors: Boehm A, Kaiser M, Li H, Spangler C, Kasper CA, Ackermann M, Kaever V, Sourjik V, Roth V, Jenal U
Bacteria… . . . → Read More: Second messenger-mediated adjustment of bacterial swimming velocity.
By Cadwell K, Patel KK, Maloney NS, Liu TC, Ng AC, Storer CE, Head RD, Xavier R, Stappenbeck TS, Virgin HW, on August 29th, 2010
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Virus-plus-susceptibility gene interaction determines Crohn’s disease gene Atg16L1 phenotypes in intestine.
Cell. 2010 Jun 25;141(7):1135-45
Authors: Cadwell K, Patel KK, Maloney NS, Liu TC, Ng AC, Storer CE… . . . → Read More: Virus-plus-susceptibility gene interaction determines Crohn’s disease gene Atg16L1 phenotypes in intestine.
By Todd JA, on August 29th, 2010
D’oh! genes and environment cause Crohn’s disease.
Cell. 2010 Jun 25;141(7):1114-6
Authors: Todd JA
Information obtained from genome-wide association studies has cracked open the biology of common chronic diseases b… . . . → Read More: D’oh! genes and environment cause Crohn’s disease.
By Davies AA, Neiss A, Ulrich HD, on August 29th, 2010
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Ubiquitylation of the 9-1-1 checkpoint clamp is independent of rad6-rad18 and DNA damage.
Cell. 2010 Jun 11;141(6):1080-7
Authors: Davies AA, Neiss A, Ulrich HD
A recent report proposed a function of… . . . → Read More: Ubiquitylation of the 9-1-1 checkpoint clamp is independent of rad6-rad18 and DNA damage.
By Devireddy LR, Hart DO, Goetz DH, Green MR, on August 29th, 2010
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A mammalian siderophore synthesized by an enzyme with a bacterial homolog involved in enterobactin production.
Cell. 2010 Jun 11;141(6):1006-17
Authors: Devireddy LR, Hart DO, Goetz DH, Green MR
Intr… . . . → Read More: A mammalian siderophore synthesized by an enzyme with a bacterial homolog involved in enterobactin production.
By thirdrev, on August 28th, 2010
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Yanping Xu, Yajamana Ramu, Zhe Lu
Voltage-gated ion channels sense transmembrane voltage changes via a paddle-shaped motif that includes the C-terminal part of the third transmembrane segment (S3b) and the N-terminal part of the fourth segment (NTS4) that harbors voltage-sensing arginines. Here, we find that residue triplets in S3b and NTS4 can . . . → Read More: A Shaker K+ Channel with a Miniature Engineered Voltage Sensor
By thirdrev, on August 6th, 2010
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Lars M. Ittner, Yazi D. Ke, Fabien Delerue, Mian Bi, Amadeus Gladbach, Janet van Eersel, Heidrun Wölfing, Billy C. Chieng, MacDonald J. Christie, Ian A. Napier, Anne Eckert, Matthias Staufenbiel, Edna Hardeman, Jürgen Götz
Alzheimer’s disease (AD) is characterized by amyloid-? (A?) and tau deposition in brain. It has emerged that . . . → Read More: Dendritic Function of Tau Mediates Amyloid-? Toxicity in Alzheimer’s Disease Mouse Models
By thirdrev, on July 22nd, 2010
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Jason J. Yi, Anthony P. Barnes, Randal Hand, Franck Polleux, Michael D. Ehlers
In the mammalian brain, the specification of a single axon and multiple dendrites occurs early in the differentiation of most neuron types. Numerous intracellular signaling events for axon specification have been described in detail. However, the identity of the . . . → Read More: TGF-? Signaling Specifies Axons during Brain Development
By thirdrev, on July 22nd, 2010
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Lei Cao, Xianglan Liu, En-Ju D. Lin, Chuansong Wang, Eugene Y. Choi, Veronique Riban, Benjamin Lin, Matthew J. During
Cancer is influenced by its microenvironment, yet broader, environmental effects also play a role but remain poorly defined. We report here that mice living in an enriched housing environment show reduced tumor growth . . . → Read More: Environmental and Genetic Activation of a Brain-Adipocyte BDNF/Leptin Axis Causes Cancer Remission and Inhibition
By thirdrev, on July 22nd, 2010
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Andrew A. Pieper, Shanhai Xie, Emanuela Capota, Sandi Jo Estill, Jeannie Zhong, Jeffrey M. Long, Ginger L. Becker, Paula Huntington, Shauna E. Goldman, Ching-Han Shen, Maria Capota, Jeremiah K. Britt, Tiina Kotti, Kerstin Ure, Daniel J. Brat, Noelle S. Williams, Karen S. MacMillan, Jacinth Naidoo, Lisa Melito, Jenny Hsieh, Jef . . . → Read More: Discovery of a Proneurogenic, Neuroprotective Chemical
By thirdrev, on July 4th, 2010
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Ju-Hyun Lee, W. Haung Yu, Asok Kumar, Sooyeon Lee, Panaiyur S. Mohan, Corrinne M. Peterhoff, Devin M. Wolfe, Marta Martinez-Vicente, Ashish C. Massey, Guy Sovak, Yasuo Uchiyama, David Westaway, Ana Maria Cuervo, Ralph A. Nixon
Macroautophagy is a lysosomal degradative pathway essential for neuron survival. Here, we show that macroautophagy requires . . . → Read More: Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations
By thirdrev, on June 22nd, 2010
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Takeshi Uemura, Sung-Jin Lee, Misato Yasumura, Tomonori Takeuchi, Tomoyuki Yoshida, Moonjin Ra, Ryo Taguchi, Kenji Sakimura, Masayoshi Mishina
Elucidation of molecular mechanisms that regulate synapse formation is required for the understanding of neural wiring, higher brain functions, and mental disorders. Despite the wealth of in vitro information, fundamental questions about how . . . → Read More: Trans-Synaptic Interaction of GluR?2 and Neurexin through Cbln1 Mediates Synapse Formation in the Cerebellum
By thirdrev, on June 22nd, 2010
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Haruki Takeuchi, Kasumi Inokuchi, Mari Aoki, Fumikazu Suto, Akio Tsuboi, Ikuo Matsuda, Misao Suzuki, Atsu Aiba, Shou Serizawa, Yoshihiro Yoshihara, Hajime Fujisawa, Hitoshi Sakano
In the mouse olfactory system, the anatomical locations of olfactory sensory neurons (OSNs) roughly correlate with their axonal projection sites along the dorsal-ventral (D-V) axis of the . . . → Read More: Sequential Arrival and Graded Secretion of Sema3F by Olfactory Neuron Axons Specify Map Topography at the Bulb
By thirdrev, on June 22nd, 2010
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Oliver B. Clarke, Alessandro T. Caputo, Adam P. Hill, Jamie I. Vandenberg, Brian J. Smith, Jacqueline M. Gulbis
Potassium channels embedded in cell membranes employ gates to regulate K+ current. While a specific constriction in the permeation pathway has historically been implicated in gating, recent reports suggest that the signature ion selectivity . . . → Read More: Domain Reorientation and Rotation of an Intracellular Assembly Regulate Conduction in Kir Potassium Channels
By thirdrev, on June 2nd, 2010
Fabio Papes, Darren W. Logan, Lisa Stowers
Potential predators emit uncharacterized chemosignals that warn receiving species of danger. Neurons that sense these stimuli remain unknown. Here we show that detection and processing of fear-evoking odors emitted from cat, rat, and snake require the function of sensory neurons in the vomeronasal organ. To investigate . . . → Read More: The Vomeronasal Organ Mediates Interspecies Defensive Behaviors through Detection of Protein Pheromone Homologs
By thirdrev, on June 2nd, 2010
Jacek Krol, Volker Busskamp, Ilona Markiewicz, Michael B. Stadler, Sebastian Ribi, Jens Richter, Jens Duebel, Silvia Bicker, Hans Jörg Fehling, Dirk Schübeler, Thomas G. Oertner, Gerhard Schratt, Miriam Bibel, Botond Roska, Witold Filipowicz
Adaptation to different levels of illumination is central to the function of the retina. Here, we demonstrate that levels of . . . → Read More: Characterizing Light-Regulated Retinal MicroRNAs Reveals Rapid Turnover as a Common Property of Neuronal MicroRNAs
By thirdrev, on June 2nd, 2010
Zheng Li, Jihoon Jo, Jie-Min Jia, Shih-Ching Lo, Daniel J. Whitcomb, Song Jiao, Kwangwook Cho, Morgan Sheng
NMDA receptor-dependent synaptic modifications, such as long-term potentiation (LTP) and long-term depression (LTD), are essential for brain development and function. LTD occurs mainly by the removal of AMPA receptors from the postsynaptic membrane, but the underlying . . . → Read More: Caspase-3 Activation via Mitochondria Is Required for Long-Term Depression and AMPA Receptor Internalization
By thirdrev, on June 2nd, 2010
Chan-Yen Ou, Vivian Y. Poon, Celine I. Maeder, Shigeki Watanabe, Emily K. Lehrman, Amy K.Y. Fu, Mikyoung Park, Wing-Yu Fu, Erik M. Jorgensen, Nancy Y. Ip, Kang Shen
Polarized trafficking of synaptic proteins to axons and dendrites is crucial to neuronal function. Through forward genetic analysis in C. elegans, we identified a cyclin . . . → Read More: Two Cyclin-Dependent Kinase Pathways Are Essential for Polarized Trafficking of Presynaptic Components
By thirdrev, on June 2nd, 2010
Christopher J. Bohlen, Avi Priel, Sharleen Zhou, David King, Jan Siemens, David Julius
Toxins have evolved to target regions of membrane ion channels that underlie ligand binding, gating, or ion permeation, and have thus served as invaluable tools for probing channel structure and function. Here, we describe a peptide toxin from the Earth . . . → Read More: A Bivalent Tarantula Toxin Activates the Capsaicin Receptor, TRPV1, by Targeting the Outer Pore Domain
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