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By thirdrev, on June 2nd, 2010
Zheng Li, Jihoon Jo, Jie-Min Jia, Shih-Ching Lo, Daniel J. Whitcomb, Song Jiao, Kwangwook Cho, Morgan Sheng
NMDA receptor-dependent synaptic modifications, such as long-term potentiation (LTP) and long-term depression (LTD), are essential for brain development and function. LTD occurs mainly by the removal of AMPA receptors from the postsynaptic membrane, but the underlying . . . → Read More: Caspase-3 Activation via Mitochondria Is Required for Long-Term Depression and AMPA Receptor Internalization
By thirdrev, on June 2nd, 2010
Chan-Yen Ou, Vivian Y. Poon, Celine I. Maeder, Shigeki Watanabe, Emily K. Lehrman, Amy K.Y. Fu, Mikyoung Park, Wing-Yu Fu, Erik M. Jorgensen, Nancy Y. Ip, Kang Shen
Polarized trafficking of synaptic proteins to axons and dendrites is crucial to neuronal function. Through forward genetic analysis in C. elegans, we identified a cyclin . . . → Read More: Two Cyclin-Dependent Kinase Pathways Are Essential for Polarized Trafficking of Presynaptic Components
By thirdrev, on June 2nd, 2010
Christopher J. Bohlen, Avi Priel, Sharleen Zhou, David King, Jan Siemens, David Julius
Toxins have evolved to target regions of membrane ion channels that underlie ligand binding, gating, or ion permeation, and have thus served as invaluable tools for probing channel structure and function. Here, we describe a peptide toxin from the Earth . . . → Read More: A Bivalent Tarantula Toxin Activates the Capsaicin Receptor, TRPV1, by Targeting the Outer Pore Domain
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