Trans-Synaptic Interaction of GluR?2 and Neurexin through Cbln1 Mediates Synapse Formation in the Cerebellum

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Takeshi Uemura, Sung-Jin Lee, Misato Yasumura, Tomonori Takeuchi, Tomoyuki Yoshida, Moonjin Ra, Ryo Taguchi, Kenji Sakimura, Masayoshi Mishina

Elucidation of molecular mechanisms that regulate synapse formation is required for the understanding of neural wiring, higher brain functions, and mental disorders. Despite the wealth of in vitro information, fundamental questions about how . . . → Read More: Trans-Synaptic Interaction of GluR?2 and Neurexin through Cbln1 Mediates Synapse Formation in the Cerebellum

Sequential Arrival and Graded Secretion of Sema3F by Olfactory Neuron Axons Specify Map Topography at the Bulb

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Haruki Takeuchi, Kasumi Inokuchi, Mari Aoki, Fumikazu Suto, Akio Tsuboi, Ikuo Matsuda, Misao Suzuki, Atsu Aiba, Shou Serizawa, Yoshihiro Yoshihara, Hajime Fujisawa, Hitoshi Sakano

In the mouse olfactory system, the anatomical locations of olfactory sensory neurons (OSNs) roughly correlate with their axonal projection sites along the dorsal-ventral (D-V) axis of the . . . → Read More: Sequential Arrival and Graded Secretion of Sema3F by Olfactory Neuron Axons Specify Map Topography at the Bulb

Domain Reorientation and Rotation of an Intracellular Assembly Regulate Conduction in Kir Potassium Channels

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Oliver B. Clarke, Alessandro T. Caputo, Adam P. Hill, Jamie I. Vandenberg, Brian J. Smith, Jacqueline M. Gulbis

Potassium channels embedded in cell membranes employ gates to regulate K+ current. While a specific constriction in the permeation pathway has historically been implicated in gating, recent reports suggest that the signature ion selectivity . . . → Read More: Domain Reorientation and Rotation of an Intracellular Assembly Regulate Conduction in Kir Potassium Channels