TGF-? Signaling Specifies Axons during Brain Development

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Jason J. Yi, Anthony P. Barnes, Randal Hand, Franck Polleux, Michael D. Ehlers

In the mammalian brain, the specification of a single axon and multiple dendrites occurs early in the differentiation of most neuron types. Numerous intracellular signaling events for axon specification have been described in detail. However, the identity of the . . . → Read More: TGF-? Signaling Specifies Axons during Brain Development

Environmental and Genetic Activation of a Brain-Adipocyte BDNF/Leptin Axis Causes Cancer Remission and Inhibition

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Lei Cao, Xianglan Liu, En-Ju D. Lin, Chuansong Wang, Eugene Y. Choi, Veronique Riban, Benjamin Lin, Matthew J. During

Cancer is influenced by its microenvironment, yet broader, environmental effects also play a role but remain poorly defined. We report here that mice living in an enriched housing environment show reduced tumor growth . . . → Read More: Environmental and Genetic Activation of a Brain-Adipocyte BDNF/Leptin Axis Causes Cancer Remission and Inhibition

Discovery of a Proneurogenic, Neuroprotective Chemical

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Andrew A. Pieper, Shanhai Xie, Emanuela Capota, Sandi Jo Estill, Jeannie Zhong, Jeffrey M. Long, Ginger L. Becker, Paula Huntington, Shauna E. Goldman, Ching-Han Shen, Maria Capota, Jeremiah K. Britt, Tiina Kotti, Kerstin Ure, Daniel J. Brat, Noelle S. Williams, Karen S. MacMillan, Jacinth Naidoo, Lisa Melito, Jenny Hsieh, Jef . . . → Read More: Discovery of a Proneurogenic, Neuroprotective Chemical