A Shaker K+ Channel with a Miniature Engineered Voltage Sensor

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Yanping Xu, Yajamana Ramu, Zhe Lu

Voltage-gated ion channels sense transmembrane voltage changes via a paddle-shaped motif that includes the C-terminal part of the third transmembrane segment (S3b) and the N-terminal part of the fourth segment (NTS4) that harbors voltage-sensing arginines. Here, we find that residue triplets in S3b and NTS4 can . . . → Read More: A Shaker K+ Channel with a Miniature Engineered Voltage Sensor

Dendritic Function of Tau Mediates Amyloid-? Toxicity in Alzheimer’s Disease Mouse Models

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Lars M. Ittner, Yazi D. Ke, Fabien Delerue, Mian Bi, Amadeus Gladbach, Janet van Eersel, Heidrun Wölfing, Billy C. Chieng, MacDonald J. Christie, Ian A. Napier, Anne Eckert, Matthias Staufenbiel, Edna Hardeman, Jürgen Götz

Alzheimer’s disease (AD) is characterized by amyloid-? (A?) and tau deposition in brain. It has emerged that . . . → Read More: Dendritic Function of Tau Mediates Amyloid-? Toxicity in Alzheimer’s Disease Mouse Models