By thirdrev, on August 28th, 2010
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Yanping Xu, Yajamana Ramu, Zhe Lu
Voltage-gated ion channels sense transmembrane voltage changes via a paddle-shaped motif that includes the C-terminal part of the third transmembrane segment (S3b) and the N-terminal part of the fourth segment (NTS4) that harbors voltage-sensing arginines. Here, we find that residue triplets in S3b and NTS4 can . . . → Read More: A Shaker K+ Channel with a Miniature Engineered Voltage Sensor
By thirdrev, on August 6th, 2010
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Lars M. Ittner, Yazi D. Ke, Fabien Delerue, Mian Bi, Amadeus Gladbach, Janet van Eersel, Heidrun Wölfing, Billy C. Chieng, MacDonald J. Christie, Ian A. Napier, Anne Eckert, Matthias Staufenbiel, Edna Hardeman, Jürgen Götz
Alzheimer’s disease (AD) is characterized by amyloid-? (A?) and tau deposition in brain. It has emerged that . . . → Read More: Dendritic Function of Tau Mediates Amyloid-? Toxicity in Alzheimer’s Disease Mouse Models