Direct Recordings of Pitch Responses from Human Auditory Cortex

Timothy D. Griffiths, Sukhbinder Kumar, William Sedley, Kirill V. Nourski, Hiroto Kawasaki, Hiroyuki Oya, Roy D. Patterson, John F. Brugge, Matthew A. Howard. Pitch is a fundamental percept with a complex relationship to the associated sound structure … . . . → Read More: Direct Recordings of Pitch Responses from Human Auditory Cortex

Modulation of Bitter Taste Perception by a Small Molecule hTAS2R Antagonist

Jay P. Slack, Anne Brockhoff, Claudia Batram, Susann Menzel, Caroline Sonnabend, Stephan Born, Maria Mercedes Galindo, Susann Kohl, Sophie Thalmann, Liliana Ostopovici-Halip, Christopher T. Simons, Ioana Ungureanu, Kees Duineveld, Cristian G. Bologa, M… . . . → Read More: Modulation of Bitter Taste Perception by a Small Molecule hTAS2R Antagonist

Crumbs/DaPKC-Dependent Apical Exclusion of Bazooka Promotes Photoreceptor Polarity Remodeling

Rhian F. Walther, Franck Pichaud. BackgroundIn Drosophila epithelial cells, specification and maintenance of the zonula adherens (za) is crucial to ensure epithelial tissue integrity. This depends on the intertwined functio…. . . . → Read More: Crumbs/DaPKC-Dependent Apical Exclusion of Bazooka Promotes Photoreceptor Polarity Remodeling

Determinants of Myosin II Cortical Localization during Cytokinesis

Ryota Uehara, Gohta Goshima, Issei Mabuchi, Ronald D. Vale, James A. Spudich, Eric R. Griffis. Myosin II is an essential component of the contractile ring that divides the cell during cytokinesis. Previous work showed that regulatory light chain (RLC) … . . . → Read More: Determinants of Myosin II Cortical Localization during Cytokinesis

History-Dependent Catastrophes Regulate Axonal Microtubule Behavior

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Tatiana Stepanova, Ihor Smal, Jeffrey van Haren, Umut Akinci, Zhe Liu, Marja Miedema, Ronald Limpens, Marco van Ham, Michael van der Reijden, Raymond Poot, Frank Grosveld, Mieke Mommaas, Erik Meijering, Niels Galjart

In Chinese hamster ovary cells, microtubules originate at the microtubule organizing center (MTOC) and grow persistently toward the . . . → Read More: History-Dependent Catastrophes Regulate Axonal Microtubule Behavior

Motion Adaptation and the Velocity Coding of Natural Scenes

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Paul D. Barnett, Karin Nordström, David C. O’Carroll

Estimating relative velocity in the natural environment is challenging because natural scenes vary greatly in contrast and spatial structure. Widely accepted correlation-based models for elementary motion detectors (EMDs) are sensitive to contrast and spatial structure and consequently generate ambiguous estimates of velocity. Identified . . . → Read More: Motion Adaptation and the Velocity Coding of Natural Scenes

Cell-Length-Dependent Microtubule Accumulation during Polarization

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Dominique Seetapun, David J. Odde

Background

Breaking cell symmetry, known as polarization, requires dynamic reorganization of microtubules (MTs) and is essential to many cellular processes, including axon formation in neurons. A critical step in polarization is believed to be the “selective stabilization” of MTs, which hypothesizes a spatial and/or temporal shift . . . → Read More: Cell-Length-Dependent Microtubule Accumulation during Polarization

The Leucokinin Pathway and Its Neurons Regulate Meal Size in Drosophila

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Bader Al-Anzi, Elena Armand, Paul Nagamei, Margaret Olszewski, Viveca Sapin, Christopher Waters, Kai Zinn, Robert J. Wyman, Seymour Benzer

Background

Total food intake is a function of meal size and meal frequency, and adjustments to these parameters allow animals to maintain a stable energy balance in changing environmental conditions. The physiological mechanisms . . . → Read More: The Leucokinin Pathway and Its Neurons Regulate Meal Size in Drosophila