The Third Reviewer

Peter Cameron, Makoto Hiroi, John Ngai & Kristin Scott

The detection of water and the regulation of water intake are essential for animals to maintain proper osmotic homeostasis1. Drosophila and other insects have gustatory sensory neurons that mediate the recognition of external water sources2, 3, 4, but little is known about the underlying . . . → Read More: The molecular basis for water taste in Drosophila

Jörn Niessing & Rainer W. Friedrich

The categorial nature of sensory, cognitive and behavioural acts indicates that the brain classifies neuronal activity patterns into discrete representations. Pattern classification may be achieved by abrupt switching between discrete activity states of neuronal circuits, but few experimental studies have directly tested this. We gradually varied . . . → Read More: Olfactory pattern classification by discrete neuronal network states

Jochen Schwenk, Michaela Metz, Gerd Zolles, Rostislav Turecek, Thorsten Fritzius, Wolfgang Bildl, Etsuko Tarusawa, Akos Kulik, Andreas Unger, Klara Ivankova, Riad Seddik, Jim Y. Tiao, Mathieu Rajalu, Johana Trojanova, Volker Rohde, Martin Gassmann, Uwe Schulte, Bernd Fakler & Bernhard Bettler

GABAB receptors are the G-protein-coupled receptors for ?-aminobutyric acid (GABA), the main inhibitory neurotransmitter in the . . . → Read More: Native GABAB receptors are heteromultimers with a family of auxiliary subunits

Yongfang Zhao, Daniel Terry, Lei Shi, Harel Weinstein, Scott C. Blanchard & Jonathan A. Javitch

Neurotransmitter:Na+ symporters (NSS) remove neurotransmitters from the synapse in a reuptake process that is driven by the Na+ gradient. Drugs that interfere with this reuptake mechanism, such as cocaine and antidepressants, profoundly influence behaviour and mood. To probe . . . → Read More: Single-molecule dynamics of gating in a neurotransmitter transporter homologue

Junko Sasaki, Satoshi Kofuji, Reietsu Itoh, Toshihiko Momiyama, Kiyohiko Takayama, Haruka Murakami, Shinsuke Chida, Yuko Tsuya, Shunsuke Takasuga, Satoshi Eguchi, Ken Asanuma, Yasuo Horie, Kouichi Miura, Elizabeth Michele Davies, Christina Mitchell, Masakazu Yamazaki, Hirokazu Hirai, Tadaomi Takenawa, Akira Suzuki & Takehiko Sasaki

Phosphorylated derivatives of phosphatidylinositol, collectively referred to as phosphoinositides, occur in the cytoplasmic leaflet . . . → Read More: The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death