Presynaptic activity regulates Na+ channel distribution at the axon initial segment

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See also related paper by Grubb and Burrone

Hiroshi Kuba, Yuki Oichi & Harunori Ohmori

Deprivation of afferent inputs in neural circuits leads to diverse plastic changes in both pre- and postsynaptic elements that restore neural activity1. The axon initial segment (AIS) is the site at which neural signals arise2, 3, and should . . . → Read More: Presynaptic activity regulates Na+ channel distribution at the axon initial segment

Activity-dependent relocation of the axon initial segment fine-tunes neuronal excitability

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See also related paper by Kuba et al.

Matthew S. Grubb & Juan Burrone

In neurons, the axon initial segment (AIS) is a specialized region near the start of the axon that is the site of action potential initiation1, 2, 3, 4, 5, 6. The precise location of the AIS varies across and . . . → Read More: Activity-dependent relocation of the axon initial segment fine-tunes neuronal excitability