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By thirdrev, on July 30th, 2010
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Biliana Marcheva, Kathryn Moynihan Ramsey, Ethan D. Buhr, Yumiko Kobayashi, Hong Su, Caroline H. Ko, Ganka Ivanova, Chiaki Omura, Shelley Mo, Martha H. Vitaterna, James P. Lopez, Louis H. Philipson, Christopher A. Bradfield, Seth D. Crosby, Lellean JeBailey, Xiaozhong Wang, Joseph S. Takahashi & Joseph Bass
The molecular clock maintains energy constancy by producing circadian . . . → Read More: Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes
By thirdrev, on July 30th, 2010
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Alexxai V. Kravitz, Benjamin S. Freeze, Philip R. L. Parker, Kenneth Kay, Myo T. Thwin, Karl Deisseroth & Anatol C. Kreitzer
Neural circuits of the basal ganglia are critical for motor planning and action selection1, 2, 3. Two parallel basal ganglia pathways have been described4, and have been proposed to exert opposing influences on motor . . . → Read More: Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry
By thirdrev, on July 30th, 2010
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Ifije E. Ohiorhenuan, Ferenc Mechler, Keith P. Purpura, Anita M. Schmid, Qin Hu & Jonathan D. Victor
Connectivity in the cortex is organized at multiple scales1, 2, 3, 4, 5, suggesting that scale-dependent correlated activity is particularly important for understanding the behaviour of sensory cortices and their function in stimulus encoding. We . . . → Read More: Sparse coding and high-order correlations in fine-scale cortical networks
By thirdrev, on July 23rd, 2010
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Yunkun Wu, Yi Yang, Sheng Ye & Youxing Jiang
Large-conductance Ca2+-gated K+ (BK) channels are essential for many biological processes such as smooth muscle contraction and neurotransmitter release1, 2, 3, 4. This group of channels can be activated synergistically by both voltage and intracellular Ca2+, with the large carboxy-terminal intracellular portion being responsible for Ca2+ . . . → Read More: Structure of the gating ring from the human large-conductance Ca2+-gated K+ channel
By thirdrev, on July 23rd, 2010
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Michael C. Schmid, Sylwia W. Mrowka, Janita Turchi, Richard C. Saunders, Melanie Wilke, Andrew J. Peters, Frank Q. Ye & David A. Leopold
Injury to the primary visual cortex (V1) leads to the loss of visual experience. Nonetheless, careful testing shows that certain visually guided behaviours can persist even in the absence of . . . → Read More: Blindsight depends on the lateral geniculate nucleus
By thirdrev, on July 23rd, 2010
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Dalila Pinto, Alistair T. Pagnamenta, Lambertus Klei, Richard Anney, Daniele Merico, Regina Regan, Judith Conroy, Tiago R. Magalhaes, Catarina Correia, Brett S. Abrahams, Joana Almeida, Elena Bacchelli, Gary D. Bader, Anthony J. Bailey, Gillian Baird, Agatino Battaglia, Tom Berney, Nadia Bolshakova, Sven Bölte, Patrick F. Bolton, Thomas Bourgeron, Sean Brennan, Jessica Brian, Susan E. . . . → Read More: Functional impact of global rare copy number variation in autism spectrum disorders
By thirdrev, on July 23rd, 2010
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Jiusheng Yan & Richard W. Aldrich
Large-conductance, voltage- and calcium-activated potassium (BK, or KCa1.1) channels are ubiquitously expressed in electrically excitable and non-excitable cells1, 2, either as ?-subunit (BK?) tetramers or together with tissue specific auxiliary ?-subunits (?1–?4)3, 4, 5. Activation of BK channels typically requires coincident membrane depolarization and elevation in free cytosolic Ca2+ . . . → Read More: LRRC26 auxiliary protein allows BK channel activation at resting voltage without calcium
By thirdrev, on July 23rd, 2010
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Hank H. Qi, Madathia Sarkissian, Gang-Qing Hu, Zhibin Wang, Arindam Bhattacharjee, D. Benjamin Gordon, Michelle Gonzales, Fei Lan, Pat P. Ongusaha, Maite Huarte, Nasser K. Yaghi, Huijun Lim, Benjamin A. Garcia, Leonardo Brizuela, Keji Zhao, Thomas M. Roberts & Yang Shi
X-linked mental retardation (XLMR) is a complex human disease that causes intellectual disability1. Causal . . . → Read More: Histone H4K20/H3K9 demethylase PHF8 regulates zebrafish brain and craniofacial development
By thirdrev, on July 23rd, 2010
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Xin Jin & Rui M. Costa
Learning new action sequences subserves a plethora of different abilities such as escaping a predator, playing the piano, or producing fluent speech. Proper initiation and termination of each action sequence is critical for the organization of behaviour, and is compromised in nigrostriatal disorders like Parkinson’s . . . → Read More: Start/stop signals emerge in nigrostriatal circuits during sequence learning
By thirdrev, on July 7th, 2010
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Luis G. Cuello, Vishwanath Jogini, D. Marien Cortes, Albert C. Pan, Dominique G. Gagnon, Olivier Dalmas, Julio F. Cordero-Morales, Sudha Chakrapani, Benoît Roux & Eduardo Perozo
The coupled interplay between activation and inactivation gating is a functional hallmark of K+ channels1, 2. This coupling has been experimentally demonstrated through ion interaction effects3, 4 . . . → Read More: Structural basis for the coupling between activation and inactivation gates in K+ channels
By thirdrev, on July 7th, 2010
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Luis G. Cuello, Vishwanath Jogini, D. Marien Cortes & Eduardo Perozo
Interconversion between conductive and non-conductive forms of the K+ channel selectivity filter underlies a variety of gating events, from flicker transitions (at the microsecond timescale) to C-type inactivation (millisecond to second timescale). Here we report the crystal structure of the Streptomyces . . . → Read More: Structural mechanism of C-type inactivation in K+ channels
By thirdrev, on July 7th, 2010
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Jonathan A. Hollander, Heh-In Im, Antonio L. Amelio, Jannet Kocerha, Purva Bali, Qun Lu, David Willoughby, Claes Wahlestedt, Michael D. Conkright & Paul J. Kenny
Cocaine addiction is characterized by a gradual loss of control over drug use, but the molecular mechanisms regulating vulnerability to this process remain unclear. Here we report that . . . → Read More: Striatal microRNA controls cocaine intake through CREB signalling
By thirdrev, on July 4th, 2010
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Michael London, Arnd Roth, Lisa Beeren, Michael Häusser & Peter E. Latham
It is well known that neural activity exhibits variability, in the sense that identical sensory stimuli produce different responses1, 2, 3, but it has been difficult to determine what this variability means. Is it noise, or does it carry important . . . → Read More: Sensitivity to perturbations in vivo implies high noise and suggests rate coding in cortex
By thirdrev, on July 4th, 2010
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Sachiko Haga, Tatsuya Hattori, Toru Sato, Koji Sato, Soichiro Matsuda, Reiko Kobayakawa, Hitoshi Sakano, Yoshihiro Yoshihara, Takefumi Kikusui & Kazushige Touhara
Various social behaviours in mice are regulated by chemical signals called pheromones that act through the vomeronasal system1, 2, 3. Exocrine gland-secreting peptide 1 (ESP1) is a 7-kDa peptide that is . . . → Read More: The male mouse pheromone ESP1 enhances female sexual receptive behaviour through a specific vomeronasal receptor
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