The Third Reviewer

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Luis G. Cuello, Vishwanath Jogini, D. Marien Cortes, Albert C. Pan, Dominique G. Gagnon, Olivier Dalmas, Julio F. Cordero-Morales, Sudha Chakrapani, Benoît Roux & Eduardo Perozo

The coupled interplay between activation and inactivation gating is a functional hallmark of K+ channels1, 2. This coupling has been experimentally demonstrated through ion interaction effects3, 4 . . . → Read More: Structural basis for the coupling between activation and inactivation gates in K+ channels

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Luis G. Cuello, Vishwanath Jogini, D. Marien Cortes & Eduardo Perozo

Interconversion between conductive and non-conductive forms of the K+ channel selectivity filter underlies a variety of gating events, from flicker transitions (at the microsecond timescale) to C-type inactivation (millisecond to second timescale). Here we report the crystal structure of the Streptomyces . . . → Read More: Structural mechanism of C-type inactivation in K+ channels

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Jonathan A. Hollander, Heh-In Im, Antonio L. Amelio, Jannet Kocerha, Purva Bali, Qun Lu, David Willoughby, Claes Wahlestedt, Michael D. Conkright & Paul J. Kenny

Cocaine addiction is characterized by a gradual loss of control over drug use, but the molecular mechanisms regulating vulnerability to this process remain unclear. Here we report that . . . → Read More: Striatal microRNA controls cocaine intake through CREB signalling