Structure of the gating ring from the human large-conductance Ca2+-gated K+ channel

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Yunkun Wu, Yi Yang, Sheng Ye & Youxing Jiang

Large-conductance Ca2+-gated K+ (BK) channels are essential for many biological processes such as smooth muscle contraction and neurotransmitter release1, 2, 3, 4. This group of channels can be activated synergistically by both voltage and intracellular Ca2+, with the large carboxy-terminal intracellular portion being responsible for Ca2+ . . . → Read More: Structure of the gating ring from the human large-conductance Ca2+-gated K+ channel

Blindsight depends on the lateral geniculate nucleus

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Michael C. Schmid, Sylwia W. Mrowka, Janita Turchi, Richard C. Saunders, Melanie Wilke, Andrew J. Peters, Frank Q. Ye & David A. Leopold

Injury to the primary visual cortex (V1) leads to the loss of visual experience. Nonetheless, careful testing shows that certain visually guided behaviours can persist even in the absence of . . . → Read More: Blindsight depends on the lateral geniculate nucleus

Functional impact of global rare copy number variation in autism spectrum disorders

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Dalila Pinto, Alistair T. Pagnamenta, Lambertus Klei, Richard Anney, Daniele Merico, Regina Regan, Judith Conroy, Tiago R. Magalhaes, Catarina Correia, Brett S. Abrahams, Joana Almeida, Elena Bacchelli, Gary D. Bader, Anthony J. Bailey, Gillian Baird, Agatino Battaglia, Tom Berney, Nadia Bolshakova, Sven Bölte, Patrick F. Bolton, Thomas Bourgeron, Sean Brennan, Jessica Brian, Susan E. . . . → Read More: Functional impact of global rare copy number variation in autism spectrum disorders