By thirdrev, on July 23rd, 2010
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Jiusheng Yan & Richard W. Aldrich
Large-conductance, voltage- and calcium-activated potassium (BK, or KCa1.1) channels are ubiquitously expressed in electrically excitable and non-excitable cells1, 2, either as ?-subunit (BK?) tetramers or together with tissue specific auxiliary ?-subunits (?1–?4)3, 4, 5. Activation of BK channels typically requires coincident membrane depolarization and elevation in free cytosolic Ca2+ . . . → Read More: LRRC26 auxiliary protein allows BK channel activation at resting voltage without calcium
By thirdrev, on July 23rd, 2010
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Hank H. Qi, Madathia Sarkissian, Gang-Qing Hu, Zhibin Wang, Arindam Bhattacharjee, D. Benjamin Gordon, Michelle Gonzales, Fei Lan, Pat P. Ongusaha, Maite Huarte, Nasser K. Yaghi, Huijun Lim, Benjamin A. Garcia, Leonardo Brizuela, Keji Zhao, Thomas M. Roberts & Yang Shi
X-linked mental retardation (XLMR) is a complex human disease that causes intellectual disability1. Causal . . . → Read More: Histone H4K20/H3K9 demethylase PHF8 regulates zebrafish brain and craniofacial development
By thirdrev, on July 23rd, 2010
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Xin Jin & Rui M. Costa
Learning new action sequences subserves a plethora of different abilities such as escaping a predator, playing the piano, or producing fluent speech. Proper initiation and termination of each action sequence is critical for the organization of behaviour, and is compromised in nigrostriatal disorders like Parkinson’s . . . → Read More: Start/stop signals emerge in nigrostriatal circuits during sequence learning
