Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes

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Biliana Marcheva, Kathryn Moynihan Ramsey, Ethan D. Buhr, Yumiko Kobayashi, Hong Su, Caroline H. Ko, Ganka Ivanova, Chiaki Omura, Shelley Mo, Martha H. Vitaterna, James P. Lopez, Louis H. Philipson, Christopher A. Bradfield, Seth D. Crosby, Lellean JeBailey, Xiaozhong Wang, Joseph S. Takahashi & Joseph Bass

The molecular clock maintains energy constancy by producing circadian . . . → Read More: Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes

Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry

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Alexxai V. Kravitz, Benjamin S. Freeze, Philip R. L. Parker, Kenneth Kay, Myo T. Thwin, Karl Deisseroth & Anatol C. Kreitzer

Neural circuits of the basal ganglia are critical for motor planning and action selection1, 2, 3. Two parallel basal ganglia pathways have been described4, and have been proposed to exert opposing influences on motor . . . → Read More: Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry

Sparse coding and high-order correlations in fine-scale cortical networks

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Ifije E. Ohiorhenuan, Ferenc Mechler, Keith P. Purpura, Anita M. Schmid, Qin Hu & Jonathan D. Victor

Connectivity in the cortex is organized at multiple scales1, 2, 3, 4, 5, suggesting that scale-dependent correlated activity is particularly important for understanding the behaviour of sensory cortices and their function in stimulus encoding. We . . . → Read More: Sparse coding and high-order correlations in fine-scale cortical networks