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See the paper In response to Kessels et al Juha Laurén1, David A. Gimbel1, Haakon B. Nygaard1, John W. Gilbert1 & Stephen M. Strittmatter1 Amyloid-? oligomers are correlated with Alzheimer’s disease progression and suppress synaptic plasticity1, 2, 3. Through unbiased expression cloning, we identified cellular prion protein (PrPC) as an amyloid-? oligomer binding protein4. PrPC was necessary for acute . . . → Read More: Laurén et al. reply See the paper Reply to Lauren et al 2009 Kessels HW, Nguyen LN, Nabavi S, Malinow R. Increased levels of brain amyloid-beta, a secreted peptide cleavage product of amyloid precursor protein (APP), is believed to be critical in the aetiology of Alzheimer’s disease. Increased amyloid-beta can cause synaptic depression, reduce the number of spine protrusions (that . . . → Read More: The prion protein as a receptor for amyloid-beta See the paper Jun Gao, Wen-Yuan Wang, Ying-Wei Mao, Johannes Gräff, Ji-Song Guan, Ling Pan, Gloria Mak, Dohoon Kim, Susan C. Su & Li-Huei Tsai The NAD-dependent deacetylase Sir2 was initially identified as a mediator of replicative lifespan in budding yeast and was subsequently shown to modulate longevity in worms and flies1, 2. Its mammalian . . . → Read More: A novel pathway regulates memory and plasticity via SIRT1 and miR-134 See the paper Andrew C. Elden, Hyung-Jun Kim, Michael P. Hart, Alice S. Chen-Plotkin, Brian S. Johnson, Xiaodong Fang, Maria Armakola, Felix Geser, Robert Greene, Min Min Lu, Arun Padmanabhan, Dana Clay-Falcone, Leo McCluskey, Lauren Elman, Denise Juhr, Peter J. Gruber, Udo Rüb, Georg Auburger, John Q. Trojanowski, Virginia M.-Y. Lee, Vivianna M. Van Deerlin, Nancy M. . . . → Read More: Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS See the paper Jonathan A. Oler, Andrew S. Fox, Steven E. Shelton, Jeffrey Rogers, Thomas D. Dyer, Richard J. Davidson, Wendy Shelledy, Terrence R. Oakes, John Blangero & Ned H. Kalin Anxious temperament (AT) in human and non-human primates is a trait-like phenotype evident early in life that is characterized by increased behavioural and physiological reactivity . . . → Read More: Amygdalar and hippocampal substrates of anxious temperament differ in their heritability |
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