Jérôme Di Giovanni, Sami Boudkkazi, Sumiko Mochida, Andrzej Bialowas, Nada Samari, Christian Lévêque, Fahamoe Youssouf, Aline Brechet, Cécile Iborra, Yves Maulet, Nicole Moutot, Dominique Debanne, Michael Seagar, Oussama El Far. Acidification of s… . . . → Read More: V-ATPase Membrane Sector Associates with Synaptobrevin to Modulate Neurotransmitter Release
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Michael B. Manookin, Michael Weick, Benjamin K. Stafford, Jonathan B. Demb. In the retina, it is not well understood how visual processing depends on AMPA- and NMDA-type glutamate receptors. Here we investigated how these receptors contribute to contra… . . . → Read More: NMDA Receptor Contributions to Visual Contrast Coding Luis Lemus, Adrián Hernández, Rogelio Luna, Antonio Zainos, Ranulfo Romo. Recent studies have reported that sensory cortices process more than one sensory modality, challenging the long-lasting concept that they process only one. However, both the id… . . . → Read More: Do Sensory Cortices Process More than One Sensory Modality during Perceptual Judgments? Thomas Akam, Dimitri M. Kullmann. The mammalian brain exhibits profuse interregional connectivity. How information flow is rapidly and flexibly switched among connected areas remains poorly understood. Task-dependent changes in th…. . . . → Read More: Oscillations and Filtering Networks Support Flexible Routing of Information Tal Laviv, Inbal Riven, Iftach Dolev, Irena Vertkin, Bartosz Balana, Paul A. Slesinger, Inna Slutsky. Presynaptic GABAB receptor (GABABR) heterodimers are composed of GB1a/GB2 subunits and critically influence synaptic and cognitive functions. Here, we… . . . → Read More: Basal GABA Regulates GABABR Conformation and Release Probability at Single Hippocampal Synapses Michaël Demarque, Nicholas C. Spitzer. Genetic programs, environmental factors, and electrical activity interact to drive the maturation of the brain. Although the cascade of transcription factors that leads to specification of the ser…. . . . → Read More: Activity-Dependent Expression of Lmx1b Regulates Specification of Serotonergic Neurons Modulating Swimming Behavior Jun B. Ding, Jaime N. Guzman, Jayms D. Peterson, Joshua A. Goldberg, D. James Surmeier. Salient stimuli redirect attention and suppress ongoing motor activity. This attentional shift is thought to rely upon thalamic signals to the striatum to shift cor… . . . → Read More: Thalamic Gating of Corticostriatal Signaling by Cholinergic Interneurons John P. Miller, Jennifer Holcomb, Ismael Al-Ramahi, Maria de Haro, Juliette Gafni, Ningzhe Zhang, Eugene Kim, Mario Sanhueza, Cameron Torcassi, Seung Kwak, Juan Botas, Robert E. Hughes, Lisa M. Ellerby. Proteolytic cleavage of huntingtin (Htt) is known… . . . → Read More: Matrix Metalloproteinases Are Modifiers of Huntingtin Proteolysis and Toxicity in Huntington’s Disease Patricio Opazo, Simon Labrecque, Cezar M. Tigaret, Arnaud Frouin, Paul W. Wiseman, Paul De Koninck, Daniel Choquet. The Ca2+/calmodulin-dependent protein kinase II (CaMKII) is critically required for the synaptic recruitment of AMPA-type glutamate rece… . . . → Read More: CaMKII Triggers the Diffusional Trapping of Surface AMPARs through Phosphorylation of Stargazin Michael A. Moskowitz, Eng H. Lo, Costantino Iadecola. This review focuses on mechanisms and emerging concepts that drive the science of stroke in a therapeutic direction. Once considered exclusively a disorder of blood vessels, growing evidence has l…. . . . → Read More: The Science of Stroke: Mechanisms in Search of Treatments Tae-Yeon Eom, Jingjun Li, E.S. Anton. Newly generated neuroblasts from the subventricular zone of the adult brain migrate as neuronal chains within a network of astroglial tubes in the rostral migratory stream. This highly directed, r…. . . . → Read More: Going Tubular in the Rostral Migratory Stream: Neurons Remodel Astrocyte Tubes to Promote Directional Migration in the Adult Brain Christoph Kayser. Multisensory integration is central to perception, and recent work drafts it as a distributed process involving many and even primary sensory cortices. Studies in behaving animals performing a mul…. . . . → Read More: The Multisensory Nature of Unisensory Cortices: A Puzzle Continued Catherine A. Thorn, Ann M. Graybiel. How the cholinergic and dopaminergic systems of the striatum interact and how these interface with the massive neocortical input to the striatum are classic questions of cardinal interest to neuro…. . . . → Read More: Pausing to Regroup: Thalamic Gating of Cortico-Basal Ganglia Networks Naoko Kaneko, Oscar Marín, Masato Koike, Yuki Hirota, Yasuo Uchiyama, Jane Y. Wu, Qiang Lu, Marc Tessier-Lavigne, Arturo Alvarez-Buylla, Hideyuki Okano, John L.R. Rubenstein, Kazunobu Sawamoto. In the long-range neuronal migration of adult mammals, yo… . . . → Read More: New Neurons Clear the Path of Astrocytic Processes for Their Rapid Migration in the Adult Brain Modulation of High-Voltage Activated Ca2+ Channels by Membrane Phosphatidylinositol 4,5-BisphosphateByung-Chang Suh, Karina Leal, Bertil Hille. Modulation of voltage-gated Ca2+ channels controls activities of excitable cells. We show that high-voltage activated Ca2+ channels are regulated by membrane phosphatidylinos…. . . . → Read More: Modulation of High-Voltage Activated Ca2+ Channels by Membrane Phosphatidylinositol 4,5-Bisphosphate Ashu Johri, M. Flint Beal. Mutant huntingtin proteolysis mediated by various proteases plays a key role in Huntington’s disease (HD) pathogenesis. In this issue of Neuron, Miller et al. have identified 11 proteases, …. . . . → Read More: Hunting-ton for New Proteases: MMPs as the New Target? Ethan S. Bromberg-Martin, Masayuki Matsumoto, Okihide Hikosaka. Dopamine has a crucial role in anticipation of motivational events. To investigate the underlying mechanisms of this process, we analyzed the activity of dopamine neurons and one of their … . . . → Read More: Distinct Tonic and Phasic Anticipatory Activity in Lateral Habenula and Dopamine Neurons Flavio Fröhlich, David A. McCormick. Local field potentials and the underlying endogenous electric fields (EFs) are traditionally considered to be epiphenomena of structured neuronal network activity. Recently, however, externally ap…. . . . → Read More: Endogenous Electric Fields May Guide Neocortical Network Activity Steven M. Nelson, Alexander L. Cohen, Jonathan D. Power, Gagan S. Wig, Francis M. Miezin, Mark E. Wheeler, Katerina Velanova, David I. Donaldson, Jeffrey S. Phillips, Bradley L. Schlaggar, Steven E. Petersen. The parietal lobe has long been viewed as a… . . . → Read More: A Parcellation Scheme for Human Left Lateral Parietal Cortex Yi-Mei Yang, Michael J. Fedchyshyn, Giovanbattista Grande, Jamila Aitoubah, Christopher W. Tsang, Hong Xie, Cameron A. Ackerley, William S. Trimble, Lu-Yang Wang. Neurotransmitter release depends critically on close spatial coupling of Ca2+ entry to sy… . . . → Read More: Septins Regulate Developmental Switching from Microdomain to Nanodomain Coupling of Ca2+ Influx to Neurotransmitter Release at a Central Synapse Nicholas A. Frost, Hari Shroff, Huihui Kong, Eric Betzig, Thomas A. Blanpied. Within dendritic spines, actin is presumed to anchor receptors in the postsynaptic density and play numerous roles regulating synaptic transmission. However, the submicron di… . . . → Read More: Single-Molecule Discrimination of Discrete Perisynaptic and Distributed Sites of Actin Filament Assembly within Dendritic Spines Gaga Kochlamazashvili, Christian Henneberger, Olena Bukalo, Elena Dvoretskova, Oleg Senkov, Patricia M.-J. Lievens, Ruth Westenbroek, Andreas K. Engel, William A. Catterall, Dmitri A. Rusakov, Melitta Schachner, Alexander Dityatev. Although the extrace… . . . → Read More: The Extracellular Matrix Molecule Hyaluronic Acid Regulates Hippocampal Synaptic Plasticity by Modulating Postsynaptic L-Type Ca2+ Channels Jesko Koehnke, Phinikoula S. Katsamba, Goran Ahlsen, Fabiana Bahna, Jeremie Vendome, Barry Honig, Lawrence Shapiro, Xiangshu Jin. Alternatively spliced ?-neurexins (?-NRXs) and neuroligins (NLs) are thought to have distinct extracellular binding affi… . . . → Read More: Splice Form Dependence of ?-Neurexin/Neuroligin Binding Interactions M. Scott Bowers, Billy T. Chen, Antonello Bonci. Experience-dependent plasticity at excitatory synapses of the mesocorticolimbic system is a fundamental brain mechanism that enables adaptation to an ever-changing environment. These synaptic resp…. . . . → Read More: AMPA Receptor Synaptic Plasticity Induced by Psychostimulants: The Past, Present, and Therapeutic Future Matthijs A.A. van der Meer, Adam Johnson, Neil C. Schmitzer-Torbert, A. David Redish. Decision-making studies across different domains suggest that decisions can arise from multiple, parallel systems in the brain: a flexible system utilizing action-out… . . . → Read More: Triple Dissociation of Information Processing in Dorsal Striatum, Ventral Striatum, and Hippocampus on a Learned Spatial Decision Task Jana Kusch, Christoph Biskup, Susanne Thon, Eckhard Schulz, Vasilica Nache, Thomas Zimmer, Frank Schwede, Klaus Benndorf. HCN pacemaker channels are tetramers mediating rhythmicity in neuronal and cardiac cells. The activity of these channels is contro… . . . → Read More: Interdependence of Receptor Activation and Ligand Binding in HCN2 Pacemaker Channels Edward O. Mann, Ole Paulsen. Synchronized network activity can be recorded as fluctuations in the local field potential (LFP). In this issue of Neuron, Fröhlich and McCormick suggest that cortical LFPs themselves contr…. . . . → Read More: Local Field Potential Oscillations as a Cortical Soliloquy L.N. van de Lagemaat, Seth G.N. Grant. A large international consortium reports in Nature on the diversity of genomic changes in families with autism spectrum disorders. Inherited and de novo mutations affecting many genes were …. . . . → Read More: Genome Variation and Complexity in the Autism Spectrum Melina R. Uncapher, J. Benjamin Hutchinson, Anthony D. Wagner. In this issue of Neuron, Nelson and colleagues report a novel parcellation of human lateral parietal cortex based on task-induced response profiles and resting-state functional connectivity… . . . → Read More: A Roadmap to Brain Mapping: Toward a Functional Map of Human Parietal Cortex Karun K. Singh, Xuecai Ge, Yingwei Mao, Laurel Drane, Konstantinos Meletis, Benjamin A. Samuels, Li-Huei Tsai. The psychiatric illness risk gene Disrupted in Schizophrenia-1 (DISC1) plays an important role in brain development; however, it is unclear h… . . . → Read More: Dixdc1 Is a Critical Regulator of DISC1 and Embryonic Cortical Development Jennifer L. Ecker, Olivia N. Dumitrescu, Kwoon Y. Wong, Nazia M. Alam, Shih-Kuo Chen, Tara LeGates, Jordan M. Renna, Glen T. Prusky, David M. Berson, Samer Hattar. Using the photopigment melanopsin, intrinsically photosensitive retinal ganglion cells (… . . . → Read More: Melanopsin-Expressing Retinal Ganglion-Cell Photoreceptors: Cellular Diversity and Role in Pattern Vision Zhiyi Wei, Mingjie Zhang. The alternative splicing of neurexins (NRXs) and neuroligins (NLs) has been implicated in specifying synaptic connections. In this issue of Neuron, Koehnke et al. took a structural approach…. . . . → Read More: A Structural Approach to Decipher the Neurexin and Neuroligin Splice Isoform Code |
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