The Third Reviewer

Ethan S. Bromberg-Martin, Masayuki Matsumoto, Okihide Hikosaka. Dopamine has a crucial role in anticipation of motivational events. To investigate the underlying mechanisms of this process, we analyzed the activity of dopamine neurons and one of their … . . . → Read More: Distinct Tonic and Phasic Anticipatory Activity in Lateral Habenula and Dopamine Neurons

Flavio Fröhlich, David A. McCormick. Local field potentials and the underlying endogenous electric fields (EFs) are traditionally considered to be epiphenomena of structured neuronal network activity. Recently, however, externally ap…. . . . → Read More: Endogenous Electric Fields May Guide Neocortical Network Activity

Steven M. Nelson, Alexander L. Cohen, Jonathan D. Power, Gagan S. Wig, Francis M. Miezin, Mark E. Wheeler, Katerina Velanova, David I. Donaldson, Jeffrey S. Phillips, Bradley L. Schlaggar, Steven E. Petersen. The parietal lobe has long been viewed as a… . . . → Read More: A Parcellation Scheme for Human Left Lateral Parietal Cortex

Yi-Mei Yang, Michael J. Fedchyshyn, Giovanbattista Grande, Jamila Aitoubah, Christopher W. Tsang, Hong Xie, Cameron A. Ackerley, William S. Trimble, Lu-Yang Wang. Neurotransmitter release depends critically on close spatial coupling of Ca2+ entry to sy… . . . → Read More: Septins Regulate Developmental Switching from Microdomain to Nanodomain Coupling of Ca2+ Influx to Neurotransmitter Release at a Central Synapse

Nicholas A. Frost, Hari Shroff, Huihui Kong, Eric Betzig, Thomas A. Blanpied. Within dendritic spines, actin is presumed to anchor receptors in the postsynaptic density and play numerous roles regulating synaptic transmission. However, the submicron di… . . . → Read More: Single-Molecule Discrimination of Discrete Perisynaptic and Distributed Sites of Actin Filament Assembly within Dendritic Spines

Gaga Kochlamazashvili, Christian Henneberger, Olena Bukalo, Elena Dvoretskova, Oleg Senkov, Patricia M.-J. Lievens, Ruth Westenbroek, Andreas K. Engel, William A. Catterall, Dmitri A. Rusakov, Melitta Schachner, Alexander Dityatev. Although the extrace… . . . → Read More: The Extracellular Matrix Molecule Hyaluronic Acid Regulates Hippocampal Synaptic Plasticity by Modulating Postsynaptic L-Type Ca2+ Channels

Jesko Koehnke, Phinikoula S. Katsamba, Goran Ahlsen, Fabiana Bahna, Jeremie Vendome, Barry Honig, Lawrence Shapiro, Xiangshu Jin. Alternatively spliced ?-neurexins (?-NRXs) and neuroligins (NLs) are thought to have distinct extracellular binding affi… . . . → Read More: Splice Form Dependence of ?-Neurexin/Neuroligin Binding Interactions

M. Scott Bowers, Billy T. Chen, Antonello Bonci. Experience-dependent plasticity at excitatory synapses of the mesocorticolimbic system is a fundamental brain mechanism that enables adaptation to an ever-changing environment. These synaptic resp…. . . . → Read More: AMPA Receptor Synaptic Plasticity Induced by Psychostimulants: The Past, Present, and Therapeutic Future

Matthijs A.A. van der Meer, Adam Johnson, Neil C. Schmitzer-Torbert, A. David Redish. Decision-making studies across different domains suggest that decisions can arise from multiple, parallel systems in the brain: a flexible system utilizing action-out… . . . → Read More: Triple Dissociation of Information Processing in Dorsal Striatum, Ventral Striatum, and Hippocampus on a Learned Spatial Decision Task

Jana Kusch, Christoph Biskup, Susanne Thon, Eckhard Schulz, Vasilica Nache, Thomas Zimmer, Frank Schwede, Klaus Benndorf. HCN pacemaker channels are tetramers mediating rhythmicity in neuronal and cardiac cells. The activity of these channels is contro… . . . → Read More: Interdependence of Receptor Activation and Ligand Binding in HCN2 Pacemaker Channels

Edward O. Mann, Ole Paulsen. Synchronized network activity can be recorded as fluctuations in the local field potential (LFP). In this issue of Neuron, Fröhlich and McCormick suggest that cortical LFPs themselves contr…. . . . → Read More: Local Field Potential Oscillations as a Cortical Soliloquy

L.N. van de Lagemaat, Seth G.N. Grant. A large international consortium reports in Nature on the diversity of genomic changes in families with autism spectrum disorders. Inherited and de novo mutations affecting many genes were …. . . . → Read More: Genome Variation and Complexity in the Autism Spectrum

Melina R. Uncapher, J. Benjamin Hutchinson, Anthony D. Wagner. In this issue of Neuron, Nelson and colleagues report a novel parcellation of human lateral parietal cortex based on task-induced response profiles and resting-state functional connectivity… . . . → Read More: A Roadmap to Brain Mapping: Toward a Functional Map of Human Parietal Cortex

Karun K. Singh, Xuecai Ge, Yingwei Mao, Laurel Drane, Konstantinos Meletis, Benjamin A. Samuels, Li-Huei Tsai. The psychiatric illness risk gene Disrupted in Schizophrenia-1 (DISC1) plays an important role in brain development; however, it is unclear h… . . . → Read More: Dixdc1 Is a Critical Regulator of DISC1 and Embryonic Cortical Development

Jennifer L. Ecker, Olivia N. Dumitrescu, Kwoon Y. Wong, Nazia M. Alam, Shih-Kuo Chen, Tara LeGates, Jordan M. Renna, Glen T. Prusky, David M. Berson, Samer Hattar. Using the photopigment melanopsin, intrinsically photosensitive retinal ganglion cells (… . . . → Read More: Melanopsin-Expressing Retinal Ganglion-Cell Photoreceptors: Cellular Diversity and Role in Pattern Vision

Zhiyi Wei, Mingjie Zhang. The alternative splicing of neurexins (NRXs) and neuroligins (NLs) has been implicated in specifying synaptic connections. In this issue of Neuron, Koehnke et al. took a structural approach…. . . . → Read More: A Structural Approach to Decipher the Neurexin and Neuroligin Splice Isoform Code