Jérôme Di Giovanni, Sami Boudkkazi, Sumiko Mochida, Andrzej Bialowas, Nada Samari, Christian Lévêque, Fahamoe Youssouf, Aline Brechet, Cécile Iborra, Yves Maulet, Nicole Moutot, Dominique Debanne, Michael Seagar, Oussama El Far. Acidification of s… . . . → Read More: V-ATPase Membrane Sector Associates with Synaptobrevin to Modulate Neurotransmitter Release
Michael B. Manookin, Michael Weick, Benjamin K. Stafford, Jonathan B. Demb. In the retina, it is not well understood how visual processing depends on AMPA- and NMDA-type glutamate receptors. Here we investigated how these receptors contribute to contra… . . . → Read More: NMDA Receptor Contributions to Visual Contrast Coding
Luis Lemus, Adrián Hernández, Rogelio Luna, Antonio Zainos, Ranulfo Romo. Recent studies have reported that sensory cortices process more than one sensory modality, challenging the long-lasting concept that they process only one. However, both the id… . . . → Read More: Do Sensory Cortices Process More than One Sensory Modality during Perceptual Judgments?
Thomas Akam, Dimitri M. Kullmann. The mammalian brain exhibits profuse interregional connectivity. How information flow is rapidly and flexibly switched among connected areas remains poorly understood. Task-dependent changes in th…. . . . → Read More: Oscillations and Filtering Networks Support Flexible Routing of Information
Tal Laviv, Inbal Riven, Iftach Dolev, Irena Vertkin, Bartosz Balana, Paul A. Slesinger, Inna Slutsky. Presynaptic GABAB receptor (GABABR) heterodimers are composed of GB1a/GB2 subunits and critically influence synaptic and cognitive functions. Here, we… . . . → Read More: Basal GABA Regulates GABABR Conformation and Release Probability at Single Hippocampal Synapses
Michaël Demarque, Nicholas C. Spitzer. Genetic programs, environmental factors, and electrical activity interact to drive the maturation of the brain. Although the cascade of transcription factors that leads to specification of the ser…. . . . → Read More: Activity-Dependent Expression of Lmx1b Regulates Specification of Serotonergic Neurons Modulating Swimming Behavior
Jun B. Ding, Jaime N. Guzman, Jayms D. Peterson, Joshua A. Goldberg, D. James Surmeier. Salient stimuli redirect attention and suppress ongoing motor activity. This attentional shift is thought to rely upon thalamic signals to the striatum to shift cor… . . . → Read More: Thalamic Gating of Corticostriatal Signaling by Cholinergic Interneurons
John P. Miller, Jennifer Holcomb, Ismael Al-Ramahi, Maria de Haro, Juliette Gafni, Ningzhe Zhang, Eugene Kim, Mario Sanhueza, Cameron Torcassi, Seung Kwak, Juan Botas, Robert E. Hughes, Lisa M. Ellerby. Proteolytic cleavage of huntingtin (Htt) is known… . . . → Read More: Matrix Metalloproteinases Are Modifiers of Huntingtin Proteolysis and Toxicity in Huntington’s Disease
Patricio Opazo, Simon Labrecque, Cezar M. Tigaret, Arnaud Frouin, Paul W. Wiseman, Paul De Koninck, Daniel Choquet. The Ca2+/calmodulin-dependent protein kinase II (CaMKII) is critically required for the synaptic recruitment of AMPA-type glutamate rece… . . . → Read More: CaMKII Triggers the Diffusional Trapping of Surface AMPARs through Phosphorylation of Stargazin
Michael A. Moskowitz, Eng H. Lo, Costantino Iadecola. This review focuses on mechanisms and emerging concepts that drive the science of stroke in a therapeutic direction. Once considered exclusively a disorder of blood vessels, growing evidence has l…. . . . → Read More: The Science of Stroke: Mechanisms in Search of Treatments
Tae-Yeon Eom, Jingjun Li, E.S. Anton. Newly generated neuroblasts from the subventricular zone of the adult brain migrate as neuronal chains within a network of astroglial tubes in the rostral migratory stream. This highly directed, r…. . . . → Read More: Going Tubular in the Rostral Migratory Stream: Neurons Remodel Astrocyte Tubes to Promote Directional Migration in the Adult Brain
Christoph Kayser. Multisensory integration is central to perception, and recent work drafts it as a distributed process involving many and even primary sensory cortices. Studies in behaving animals performing a mul…. . . . → Read More: The Multisensory Nature of Unisensory Cortices: A Puzzle Continued
Catherine A. Thorn, Ann M. Graybiel. How the cholinergic and dopaminergic systems of the striatum interact and how these interface with the massive neocortical input to the striatum are classic questions of cardinal interest to neuro…. . . . → Read More: Pausing to Regroup: Thalamic Gating of Cortico-Basal Ganglia Networks
Naoko Kaneko, Oscar Marín, Masato Koike, Yuki Hirota, Yasuo Uchiyama, Jane Y. Wu, Qiang Lu, Marc Tessier-Lavigne, Arturo Alvarez-Buylla, Hideyuki Okano, John L.R. Rubenstein, Kazunobu Sawamoto. In the long-range neuronal migration of adult mammals, yo… . . . → Read More: New Neurons Clear the Path of Astrocytic Processes for Their Rapid Migration in the Adult Brain
Byung-Chang Suh, Karina Leal, Bertil Hille. Modulation of voltage-gated Ca2+ channels controls activities of excitable cells. We show that high-voltage activated Ca2+ channels are regulated by membrane phosphatidylinos…. . . . → Read More: Modulation of High-Voltage Activated Ca2+ Channels by Membrane Phosphatidylinositol 4,5-Bisphosphate
Ashu Johri, M. Flint Beal. Mutant huntingtin proteolysis mediated by various proteases plays a key role in Huntington’s disease (HD) pathogenesis. In this issue of Neuron, Miller et al. have identified 11 proteases, …. . . . → Read More: Hunting-ton for New Proteases: MMPs as the New Target?