The Third Reviewer

Alcohol Excites Cerebellar Golgi Cells by Inhibiting the Na+/K+ ATPase

Neuropsychopharmacology 35,
1984 (August 2010). doi:10.1038/npp.2010.76

Authors: Paolo Botta, Fabio M Simões de Souza, Thomas Sangr… . . . → Read More: Alcohol Excites Cerebellar Golgi Cells by Inhibiting the Na+/K+ ATPase

Ethanol Blocks Long-Term Potentiation of GABAergic Synapses in the Ventral Tegmental Area Involving μ-Opioid Receptors

Neuropsychopharmacology 35,
1841 (August 2010). doi:10.1038/npp.2010.51

Authors: Yan-zhong Guan… . . . → Read More: Ethanol Blocks Long-Term Potentiation of GABAergic Synapses in the Ventral Tegmental Area Involving ?-Opioid Receptors

Striatal Dopamine Mediates the Interface between Motivational and Cognitive Control in Humans: Evidence from Genetic Imaging

Neuropsychopharmacology 35,
1943 (August 2010). doi:10.1038/npp.2010.68

Authors: Esther Aarts,… . . . → Read More: Striatal Dopamine Mediates the Interface between Motivational and Cognitive Control in Humans: Evidence from Genetic Imaging

Prefrontal Cortical Changes Following Cognitive Training in Patients with Chronic Schizophrenia: Effects of Practice, Generalization, and Specificity

Neuropsychopharmacology 35,
1850 (August 2010). doi:10.1038/npp.2010.5… . . . → Read More: Prefrontal Cortical Changes Following Cognitive Training in Patients with Chronic Schizophrenia: Effects of Practice, Generalization, and Specificity

An Anxiolytic Response Exerted by β3-Adrenoreceptor Activation: Correlation with an Enhanced Subset of Gabaergic Synaptic Responses

Neuropsychopharmacology 35,
1839 (August 2010). doi:10.1038/npp.2010.73

Author: Ro… . . . → Read More: An Anxiolytic Response Exerted by ?3-Adrenoreceptor Activation: Correlation with an Enhanced Subset of Gabaergic Synaptic Responses

Epistasis of the DRD2/ANKK1 Taq Ia and the BDNF Val66Met Polymorphism Impacts Novelty Seeking and Harm Avoidance

Neuropsychopharmacology 35,
1860 (August 2010). doi:10.1038/npp.2010.55

Authors: Christian Montag, Seb… . . . → Read More: Epistasis of the DRD2/ANKK1 Taq Ia and the BDNF Val66Met Polymorphism Impacts Novelty Seeking and Harm Avoidance

The Endocannabinoid System Tonically Regulates Inhibitory Transmission and Depresses the Effect of Ethanol in Central Amygdala

Neuropsychopharmacology 35,
1962 (August 2010). doi:10.1038/npp.2010.70

Authors: Marisa Robe… . . . → Read More: The Endocannabinoid System Tonically Regulates Inhibitory Transmission and Depresses the Effect of Ethanol in Central Amygdala

Dual Tasking and Working Memory in Alcoholism: Relation to Frontocerebellar Circuitry

Neuropsychopharmacology 35,
1868 (August 2010). doi:10.1038/npp.2010.56

Authors: Sandra Chanraud, Anne-Lise Pitel, Torsten Rohlfing, … . . . → Read More: Dual Tasking and Working Memory in Alcoholism: Relation to Frontocerebellar Circuitry

Nitric Oxide Synthase Mediates the Ability of Darbepoetin Alfa to Improve the Cognitive Performance of STOP Null Mice

Neuropsychopharmacology 35,
2005 (August 2010). doi:10.1038/npp.2010.66

Authors: Kosuke Kajitani, Mic… . . . → Read More: Nitric Oxide Synthase Mediates the Ability of Darbepoetin Alfa to Improve the Cognitive Performance of STOP Null Mice

Cannabidiol Attenuates the Appetitive Effects of Δ9-Tetrahydrocannabinol in Humans Smoking Their Chosen Cannabis

Neuropsychopharmacology 35,
1879 (August 2010). doi:10.1038/npp.2010.58

Authors: Celia JA Morgan, Tom… . . . → Read More: Cannabidiol Attenuates the Appetitive Effects of ?9-Tetrahydrocannabinol in Humans Smoking Their Chosen Cannabis

Behavioral Stress May Increase the Rewarding Valence of Cocaine-Associated Cues Through a Dynorphin/κ-Opioid Receptor-Mediated Mechanism without Affecting Associative Learning or Memory Retrieval Mechanisms

Neuropsychopharmacol… . . . → Read More: Behavioral Stress May Increase the Rewarding Valence of Cocaine-Associated Cues Through a Dynorphin/?-Opioid Receptor-Mediated Mechanism without Affecting Associative Learning or Memory Retrieval Mechanisms

Lateral Paracapsular GABAergic Synapses in the Basolateral Amygdala Contribute to the Anxiolytic Effects of β3 Adrenoceptor Activation

Neuropsychopharmacology 35,
1886 (August 2010). doi:10.1038/npp.2010.59

Authors… . . . → Read More: Lateral Paracapsular GABAergic Synapses in the Basolateral Amygdala Contribute to the Anxiolytic Effects of ?3 Adrenoceptor Activation

Reboxetine Enhances the Olanzapine-Induced Antipsychotic-Like Effect, Cortical Dopamine Outflow and NMDA Receptor-Mediated Transmission

Neuropsychopharmacology 35,
1952 (August 2010). doi:10.1038/npp.2010.69

Authors: Mo… . . . → Read More: Reboxetine Enhances the Olanzapine-Induced Antipsychotic-Like Effect, Cortical Dopamine Outflow and NMDA Receptor-Mediated Transmission

Calcium/Calmodulin-Dependent Protein Kinase II Mediates Hippocampal Glutamatergic Plasticity During Benzodiazepine Withdrawal

Neuropsychopharmacology 35,
1897 (August 2010). doi:10.1038/npp.2010.61

Authors: Guofu Sh… . . . → Read More: Calcium/Calmodulin-Dependent Protein Kinase II Mediates Hippocampal Glutamatergic Plasticity During Benzodiazepine Withdrawal

Association of the Anxiogenic and Alerting Effects of Caffeine with ADORA2A and ADORA1 Polymorphisms and Habitual Level of Caffeine Consumption

Neuropsychopharmacology 35,
1973 (August 2010). doi:10.1038/npp.2010.71

Aut… . . . → Read More: Association of the Anxiogenic and Alerting Effects of Caffeine with ADORA2A and ADORA1 Polymorphisms and Habitual Level of Caffeine Consumption

Effect of Modafinil on Impairments in Neurobehavioral Performance and Learning Associated with Extended Wakefulness and Circadian Misalignment

Neuropsychopharmacology 35,
1910 (August 2010). doi:10.1038/npp.2010.63

Auth… . . . → Read More: Effect of Modafinil on Impairments in Neurobehavioral Performance and Learning Associated with Extended Wakefulness and Circadian Misalignment

Antipsychotics Associated with the Development of Type 2 Diabetes in Antipsychotic-Naïve Schizophrenia Patients

Neuropsychopharmacology 35,
1997 (August 2010). doi:10.1038/npp.2010.78

Authors: Jimmi Nielsen, Sø… . . . → Read More: Antipsychotics Associated with the Development of Type 2 Diabetes in Antipsychotic-Naïve Schizophrenia Patients

Variation in Nicotinic Acetylcholine Receptor Genes is Associated with Multiple Substance Dependence Phenotypes

Neuropsychopharmacology 35,
1921 (August 2010). doi:10.1038/npp.2010.64

Authors: Richard Sherva, Henry R Kr… . . . → Read More: Variation in Nicotinic Acetylcholine Receptor Genes is Associated with Multiple Substance Dependence Phenotypes

Noradrenergic α1 Receptors as a Novel Target for the Treatment of Nicotine Addiction

Neuropsychopharmacology 35,
2006 (August 2010). doi:10.1038/npp.2010.62

Authors: Benoit Forget, Carrie Wertheim, Paola Mascia, Ab… . . . → Read More: Noradrenergic ?1 Receptors as a Novel Target for the Treatment of Nicotine Addiction

Patrick N McCormick, Shitij Kapur, Ariel Graff-Guerrero, Roger Raymond, José N Nobrega and . . . → Read More: The Antipsychotics Olanzapine, Risperidone, Clozapine, and Haloperidol Are D2-Selective Ex Vivo but Not In Vitro

Audrey Versini, Nicolas Ramoz, Yann Le Strat, Susann Scherag, Stefan Ehrlich, Claudette Boni, Anke Hinney, Johannes Hebebrand, Lucia Romo, Julien-Daniel Guelfi . . . → Read More: Estrogen Receptor 1 Gene (ESR1) is Associated with Restrictive Anorexia Nervosa

Eoin C O’Connor, Hans S Crombag, Andy N Mead and . . . → Read More: The mGluR5 Antagonist MTEP Dissociates the Acquisition of Predictive and Incentive Motivational Properties of Reward-Paired Stimuli in Mice

James David Jentsch, Jason A Woods, Stephanie M Groman . . . → Read More: Behavioral Characteristics and Neural Mechanisms Mediating Performance in a Rodent Version of the Balloon Analog Risk Task

Bjoern Lex . . . → Read More: Disconnection of the Entorhinal Cortex and Dorsomedial Striatum Impairs the Sensitivity to Instrumental Contingency Degradation

Katherine W Falenski, Andrew J Thorpe, Joel E Schlosburg, Benjamin F Cravatt, Rehab A Abdullah, Tricia H Smith, Dana E Selley, Aron H Lichtman and . . . → Read More: FAAH?/? Mice Display Differential Tolerance, Dependence, and Cannabinoid Receptor Adaptation After ?9-Tetrahydrocannabinol and Anandamide Administration

Abigail Polter, Eléonore Beurel, Sufen Yang, Rakesha Garner, Ling Song, Courtney A Miller, J David Sweatt, Lori McMahon, Alfred A Bartolucci, Xiaohua Li and . . . → Read More: Deficiency in the Inhibitory Serine-Phosphorylation of Glycogen Synthase Kinase-3 Increases Sensitivity to Mood Disturbances

Benoit Forget, Carrie Wertheim, Paola Mascia, Abhiram Pushparaj, Steven R Goldberg and . . . → Read More: Noradrenergic ? 1 Receptors as a Novel Target for the Treatment of Nicotine Addiction

In Kyoon Lyoo, Stephen R Dager, Jieun E Kim, Sujung J Yoon, Seth D Friedman, David L Dunner and . . . → Read More: Lithium-Induced Gray Matter Volume Increase As a Neural Correlate of Treatment Response in Bipolar Disorder: A Longitudinal Brain Imaging Study

Michelle C Potter, Greg I Elmer, Richard Bergeron, Edson X Albuquerque, Paolo Guidetti, Hui-Qiu Wu . . . → Read More: Reduction of Endogenous Kynurenic Acid Formation Enhances Extracellular Glutamate, Hippocampal Plasticity, and Cognitive Behavior

Robert D Levitan, Allan S Kaplan, Caroline Davis, Raymond W Lam and . . . → Read More: A Season-of-Birth/DRD4 Interaction Predicts Maximal Body Mass Index in Women with Bulimia Nervosa

Kosuke Kajitani, Michael Thorne, Michel Samson and . . . → Read More: Nitric Oxide Synthase Mediates the Ability of Darbepoetin Alfa to Improve the Cognitive Performance of STOP Null Mice

Stefano Marenco, Antonina A Savostyanova, Jan Willem van der Veen, Matthew Geramita, Alexa Stern, Alan S Barnett, Bhaskar Kolachana, Eugenia Radulescu, Fengyu Zhang, Joseph H Callicott, Richard E Straub, Jun Shen and . . . → Read More: Genetic Modulation of GABA Levels in the Anterior Cingulate Cortex by GAD1 and COMT

Wen Hu, Mingyue Zhang, Boldizsár Czéh, Gabriele Flügge . . . → Read More: Stress Impairs GABAergic Network Function in the Hippocampus by Activating Nongenomic Glucocorticoid Receptors and Affecting the Integrity of the Parvalbumin-Expressing Neuronal Network

Pingxing Xie, Henry R Kranzler, James Poling, Murray B Stein, Raymond F Anton, Lindsay A Farrer . . . → Read More: Interaction of FKBP5 with Childhood Adversity on Risk for Post-Traumatic Stress Disorder

Alec Roy, Elena Gorodetsky, Qiaoping Yuan, David Goldman and . . . → Read More: Interaction of FKBP5, a Stress-Related Gene, with Childhood Trauma Increases the Risk for Attempting Suicide

Maite Solas, Bárbara Aisa, María C Mugueta, Joaquín Del Río, Rosa M Tordera and . . . → Read More: Interactions Between Age, Stress and Insulin on Cognition: Implications for Alzheimer’s Disease

Charles Hutchison Keesor West, James Carl Ritchie and . . . → Read More: Paroxetine-Induced Increase in Activity of Locus Coeruleus Neurons in Adolescent Rats: Implication of a Countertherapeutic Effect of an Antidepressant

Kobayashi T, Washiyama K, Ikeda K.
Atomoxetine and reboxetine are commonly used as selective norepinephrine reuptake inhibitors (NRIs) for the treatment of attention-deficit-hyperactivity disorder and depression, respectively. Furthermore, recent studies have suggested that NRIs may be useful for the treatment of several other psychiatric disorders. However, the molecular mechanisms underlying the various effects of NRIs have not . . . → Read More: Inhibition of G-protein-activated inwardly rectifying K+ channels by the selective norepinephrine reuptake inhibitors atomoxetine and reboxetine.

Salvadore G, Cornwell BR, Sambataro F, Latov D, Colon-Rosario V, Carver F, Holroyd T, DiazGranados N, Machado-Vieira R, Grillon C, Drevets WC, Zarate CA Jr.
Pregenual anterior cingulate cortex (pgACC) hyperactivity differentiates treatment responders from non-responders to various pharmacological antidepressant interventions, including ketamine, an N-methyl-D-aspartate receptor antagonist. Evidence of pgACC hyperactivition during non-emotional working memory tasks in . . . → Read More: Anterior cingulate desynchronization and functional connectivity with the amygdala during a working memory task predict rapid antidepressant response to ketamine.

Xu J, DeVito EE, Worhunsky PD, Carroll KM, Rounsaville BJ, Potenza MN.
Cocaine dependence is associated with white matter impairments that may compromise cognitive function and hence drug users’ abilities to engage in and benefit from treatment. The main aim of this study was to assess whether white matter integrity correlates with treatment outcome measures in cocaine . . . → Read More: White matter integrity is associated with treatment outcome measures in cocaine dependence.

Maccarrone M, Rossi S, Bari M, De Chiara V, Rapino C, Musella A, Bernardi G, Bagni C, Centonze D.
Transcriptional silencing of the gene encoding the fragile X mental retardation protein (FMRP) causes fragile X syndrome (FXS). FMRP acts as a translational repressor at central synapses, and molecular and synaptic plasticity studies have shown that the absence . . . → Read More: Abnormal mGlu 5 receptor-endocannabinoid coupling in mice lacking FMRP and BC1 RNA.

Adinoff B, Devous MD Sr, Williams MJ, Best SE, Harris TS, Minhajuddin A, Zielinski T, Cullum M.
Changes in the brain’s cholinergic receptor systems underlie several neuropsychiatric disorders, including Alzheimer’s disease, schizophrenia, and depression. An emerging preclinical literature also reveals that acetylcoholine may have an important function in addictive processes, including reward, learning, and memory. This study . . . → Read More: Altered neural cholinergic receptor systems in cocaine-addicted subjects.

Petrovsky N, Quednow BB, Ettinger U, Schmechtig A, M?ssner R, Collier DA, K?hn KU, Maier W, Wagner M, Kumari V.
Attentional gating deficits, commonly measured by prepulse inhibition (PPI) of the acoustic startle response (ASR), have been established as an endophenotype of schizophrenia. Prepulse inhibition is heritable and has been associated with polymorphisms in serotonin and dopamine . . . → Read More: Sensorimotor gating is associated with CHRNA3 polymorphisms in schizophrenia and healthy volunteers.

Escribano L, Sim?n AM, Gimeno E, Cuadrado-Tejedor M, de Maturana RL, Garc?a-Osta A, Ricobaraza A, P?rez-Mediavilla A, R?o JD, Frechilla D.
Clinical studies suggest that agonists at peroxisome proliferator-activated receptor gamma (PPARgamma) may exert beneficial effects in patients with mild-to-moderate Alzheimer’s disease (AD), but the mechanism for the potential therapeutic interest of this class of drugs . . . → Read More: Rosiglitazone rescues memory impairment in Alzheimer’s transgenic mice: mechanisms involving a reduced amyloid and tau pathology.

Maayan L, Vakhrusheva J, Correll CU.
Antipsychotic-related weight gain and metabolic effects are a critical outcome for patients requiring these medications. A literature search using MEDLINE, Web of Science, PsycNET, and EMBASE for randomized, open and double-blind, placebo-controlled trials of medications targeting antipsychotic-induced weight gain was performed. Primary outcome measures were change and endpoint values in . . . → Read More: Effectiveness of medications used to attenuate antipsychotic-related weight gain and metabolic abnormalities: a systematic review and meta-analysis.

Arad M, Weiner I.
Women with schizophrenia have later onset and better response to antipsychotic drugs (APDs) than men during reproductive years, but the menopausal period is associated with increased symptom severity and reduced treatment response. Estrogen replacement therapy has been suggested as beneficial but clinical data are inconsistent. Latent inhibition (LI), the capacity to ignore irrelevant . . . → Read More: Contrasting effects of increased and decreased dopamine transmission on latent inhibition in ovariectomized rats and their modulation by 17beta-estradiol: an animal model of menopausal psychosis?

Chen CC, Yang CH, Huang CC, Hsu KS.
The mossy fiber synapses onto hippocampal CA3 neurons show unique molecular features and a wide dynamic range of plasticity. Although acute stress has been well recognized to alter bidirectional long-term synaptic plasticity in the hippocampal CA1 region and dentate gyrus, it remains unclear whether the same effect may also . . . → Read More: Acute stress impairs hippocampal mossy fiber-CA3 long-term potentiation by enhancing cAMP-specific phosphodiesterase 4 activity.

Unschuld PG, Ising M, Roeske D, Erhardt A, Specht M, Kloiber S, Uhr M, M?ller-Myhsok B, Holsboer F, Binder EB.
Galanin (GAL) is an estrogen-inducible neuropeptide, highly expressed in brain regions reported to be involved in regulation of mood and anxiety. GAL possibly has a direct modulatory effect on hypothalamic-pituitary-adrenal (HPA)-axis regulation. Recent data from pharmacological and . . . → Read More: Gender-specific association of galanin polymorphisms with HPA-axis dysregulation, symptom severity, and antidepressant treatment response.

Ito R, Canseliet M.
Behaviorally sensitizing regimen of amphetamine (AMPH) exposure has diverse effects on learning, memory, and cognition that are likely to be a consequence of long-term neural adaptations occurring in the cortico-limbic-striatal circuitry. In particular, altered dopamine signaling in the nucleus accumbens and medial prefrontal cortex has been implicated to underlie AMPH-induced changes in . . . → Read More: Amphetamine exposure selectively enhances hippocampus-dependent spatial learning and attenuates amygdala-dependent cue learning.

Axel AM, Mikkelsen JD, Hansen HH.
Tesofensine is a novel monoamine reuptake inhibitor that inhibits both norepinephrine, 5-HT, and dopamine (DA) reuptake function. Tesofensine is currently in clinical development for the treatment of obesity, however, the pharmacological basis for its strong effect in obesity management is not clarified. Using a rat model of diet-induced obesity (DIO), we . . . → Read More: Tesofensine, a novel triple monoamine reuptake inhibitor, induces appetite suppression by indirect stimulation of alpha1 adrenoceptor and dopamine D1 receptor pathways in the diet-induced obese rat.

Lauro C, Cipriani R, Catalano M, Trettel F, Chece G, Brusadin V, Antonilli L, van Rooijen N, Eusebi F, Fredholm BB, Limatola C.
Fractalkine-CX3CL1 is a neuron-associated chemokine, which modulates microglia-induced neurotoxicity activating the specific and unique receptor CX3CR1. CX3CL1-CX3CR1 interaction modulates the release of cytokines from microglia, reducing the level of tumor necrosis factor-alpha, interleukin-1-beta, and . . . → Read More: Adenosine A1 receptors and microglial cells mediate CX3CL1-induced protection of hippocampal neurons against Glu-induced death.

Chen GG, Fiori LM, Moquin L, Gratton A, Mamer O, Mechawar N, Turecki G.
Recent studies have implicated alterations in the expression of polyamine-related genes in the brains of suicide completers including widespread downregulation of spermidine-spermine N1-acetyltransferase, the key enzyme in polyamine catabolism, suggesting compensatory mechanisms attempting to increase brain levels of polyamines. Given the complexity . . . → Read More: Evidence of altered polyamine concentrations in cerebral cortex of suicide completers.

Nothdurfter C, Tanasic S, Di Benedetto B, Rammes G, Wagner EM, Kirmeier T, Ganal V, Kessler JS, Rein T, Holsboer F, Rupprecht R.
Because of the biochemical colocalization of the 5-HT(3) receptor and antidepressants within raft-like domains and their antagonistic effects at this ligand-gated ion channel, we investigated the impact of lipid raft integrity for . . . → Read More: Impact of lipid raft integrity on 5-HT3 receptor function and its modulation by antidepressants.

Simms JA, Bito-Onon JJ, Chatterjee S, Bartlett SE.
A major obstacle in the development of new medications for the treatment of alcohol use disorders (AUDs) has been the lack of preclinical, oral ethanol consumption paradigms that elicit high consumption. We have previously shown that rats exposed to 20% ethanol intermittently in a two-bottle choice paradigm will consume . . . → Read More: Long-Evans rats acquire operant self-administration of 20% ethanol without sucrose fading.

Ghiglieri V, Sgobio C, Patassini S, Bagetta V, Fejtova A, Giamp? C, Marinucci S, Heyden A, Gundelfinger ED, Fusco FR, Calabresi P, Picconi B.
In mice lacking the central domain of the presynaptic scaffold Bassoon the occurrence of repeated cortical seizures induces cell-type-specific plasticity changes resulting in a general enhancement of the feedforward inhibition within the . . . → Read More: TrkB-BDNF-dependent striatal plasticity and behavior in a genetic model of epilepsy: modulation by valproic acid.

Cattaneo A, Sesta A, Calabrese F, Nielsen G, Riva MA, Gennarelli M.
Major depression is a disease characterized by an inability of neuronal systems to show appropriate adaptive plasticity especially under challenging conditions, such as stress. Conversely, pharmacological intervention may normalize such defects through the modulation of factors that might act in concert for the functional . . . → Read More: The expression of VGF is reduced in leukocytes of depressed patients and it is restored by effective antidepressant treatment.