Segment-Specific Neuronal Subtype Specification by the Integration of Anteroposterior and Temporal Cues

Daniel Karlsson, Magnus Baumgardt, Stefan Thor

The generation of distinct neuronal subtypes at different axial levels relies upon both anteroposterior and temporal cues. However, the integration between these cues is poorly understood. In the Drosophila central nervous system, the segmentally repeated neuroblast 5–6 generates a unique group of neurons, the Apterous (Ap) . . . → Read More: Segment-Specific Neuronal Subtype Specification by the Integration of Anteroposterior and Temporal Cues

Directing Astroglia from the Cerebral Cortex into Subtype Specific Functional Neurons

Christophe Heinrich, Robert Blum, Sergio Gascón, Giacomo Masserdotti, Pratibha Tripathi, Rodrigo Sánchez, Steffen Tiedt, Timm Schroeder, Magdalena Götz, Benedikt Berninger

Astroglia from the postnatal cerebral cortex can be reprogrammed in vitro to generate neurons following forced expression of neurogenic transcription factors, thus opening new avenues towards a potential use of endogenous astroglia . . . → Read More: Directing Astroglia from the Cerebral Cortex into Subtype Specific Functional Neurons