Alterations of cortical pyramidal neurons in mice lacking high-affinity nicotinic receptors [Neuroscience]

<p>The neuronal nicotinic acetylcholine receptors (nAChRs) are allosteric membrane proteins involved in multiple cognitive processes, including attention, learning, and memory…. . . . → Read More: Alterations of cortical pyramidal neurons in mice lacking high-affinity nicotinic receptors [Neuroscience]

The orphan nuclear hormone receptor ERR{beta} controls rod photoreceptor survival [Neuroscience]

<p>Mutation of rod photoreceptor-enriched transcription factors is a major cause of inherited blindness. We identified the orphan nuclear hormone receptor… . . . → Read More: The orphan nuclear hormone receptor ERR{beta} controls rod photoreceptor survival [Neuroscience]

Hyaluronan blocks oligodendrocyte progenitor maturation and remyelination through TLR2 [Neuroscience]

<p>Failure of remyelination is largely responsible for sustained neurologic symptoms in multiple sclerosis (MS). MS lesions contain hyaluronan deposits that… . . . → Read More: Hyaluronan blocks oligodendrocyte progenitor maturation and remyelination through TLR2 [Neuroscience]

Characterization and reversal of synaptic defects in the amygdala in a mouse model of fragile X syndrome [Neuroscience]

<p>Fragile X syndrome (FXS), a common inherited form of mental impairment and autism, is caused by transcriptional silencing of the… . . . → Read More: Characterization and reversal of synaptic defects in the amygdala in a mouse model of fragile X syndrome [Neuroscience]

Topographically specific regeneration of sensory axons in the spinal cord [Neuroscience]

<p>Artemin, a member of the glial-derived neurotrophic factor family, promotes robust regeneration of sensory axons after dorsal root crush. We… . . . → Read More: Topographically specific regeneration of sensory axons in the spinal cord [Neuroscience]

A kinesin signaling complex mediates the ability of GSK-3{beta} to affect mood-associated behaviors [Neuroscience]

<p>Lithium has been the gold standard in the treatment of bipolar disorder (BPD) for 60 y. Like lithium, glycogen synthase… . . . → Read More: A kinesin signaling complex mediates the ability of GSK-3{beta} to affect mood-associated behaviors [Neuroscience]

Sialidase enhances recovery from spinal cord contusion injury [Neuroscience]

<p>Axons fail to regenerate in the injured spinal cord, limiting motor and autonomic recovery and contributing to long-term morbidity. Endogenous… . . . → Read More: Sialidase enhances recovery from spinal cord contusion injury [Neuroscience]

Tracking differentiating neural progenitors in pluripotent cultures using microRNA-regulated lentiviral vectors [Neuroscience]

<p>In this study, we have used a microRNA-regulated lentiviral reporter system to visualize and segregate differentiating neuronal cells in pluripotent… . . . → Read More: Tracking differentiating neural progenitors in pluripotent cultures using microRNA-regulated lentiviral vectors [Neuroscience]

Dissociation of duration-based and beat-based auditory timing in cerebellar degeneration [Neuroscience]

<p>This work tests the hypothesis that the cerebellum is critical to the perception of the timing of sensory events. Auditory… . . . → Read More: Dissociation of duration-based and beat-based auditory timing in cerebellar degeneration [Neuroscience]

Structure of the full-length Shaker potassium channel Kv1.2 by normal-mode-based X-ray crystallographic refinement [Biophysics_And_Computational_Biology]

<p>Voltage-dependent potassium channels (Kv) are homotetramers composed of four voltage sensors and one pore domain. Because of high-level structural flexibility,… . . . → Read More: Structure of the full-length Shaker potassium channel Kv1.2 by normal-mode-based X-ray crystallographic refinement [Biophysics_And_Computational_Biology]

Inaugural Article: Functional specificity in the human brain: A window into the functional architecture of the mind [Neuroscience]

<p>Is the human mind/brain composed of a set of highly specialized components, each carrying out a specific aspect of human… . . . → Read More: Inaugural Article: Functional specificity in the human brain: A window into the functional architecture of the mind [Neuroscience]