Interneurons of the cerebellar cortex toggle Purkinje cells between up and down states [Neuroscience]

<p>We demonstrate that single interneurons can toggle the output neurons of the cerebellar cortex (the Purkinje cells) between their two… . . . → Read More: Interneurons of the cerebellar cortex toggle Purkinje cells between up and down states [Neuroscience]

Paired neuron recordings in the prefrontal and inferotemporal cortices reveal that spatial selection precedes object identification during visual search [Psychological_And_Cognitive_Sciences-SS]

<p>We addressed the question of how we locate and identify objects in complex natural environments by simultaneously recording single neurons… . . . → Read More: Paired neuron recordings in the prefrontal and inferotemporal cortices reveal that spatial selection precedes object identification during visual search [Psychological_And_Cognitive_Sciences-SS]

Presynaptic dopaminergic compartment determines the susceptibility to L-DOPA-induced dyskinesia in rats [Neuroscience]

<p>Drug-induced dyskinesias in dopamine-denervated animals are known to depend on both pre- and postsynaptic changes of the nigrostriatal circuitry. In… . . . → Read More: Presynaptic dopaminergic compartment determines the susceptibility to L-DOPA-induced dyskinesia in rats [Neuroscience]

Coexpression of {delta}- and {micro}-opioid receptors in nociceptive sensory neurons [Neuroscience]

Morphine-induced analgesia and antinociceptive tolerance are known to be modulated by interaction between -opioid receptors (DORs) and µ-opioid receptors (MORs)… . . . → Read More: Coexpression of {delta}- and {micro}-opioid receptors in nociceptive sensory neurons [Neuroscience]

Tbr1 regulates regional and laminar identity of postmitotic neurons in developing neocortex [Neuroscience]

<p>Areas and layers of the cerebral cortex are specified by genetic programs that are initiated in progenitor cells and then,… . . . → Read More: Tbr1 regulates regional and laminar identity of postmitotic neurons in developing neocortex [Neuroscience]

Correlated memory defects and hippocampal dendritic spine loss after acute stress involve corticotropin-releasing hormone signaling [Neuroscience]

<p>Stress affects the hippocampus, a brain region crucial for memory. In rodents, acute stress may reduce density of dendritic spines,… . . . → Read More: Correlated memory defects and hippocampal dendritic spine loss after acute stress involve corticotropin-releasing hormone signaling [Neuroscience]

Similar patterns of cortical expansion during human development and evolution [Neuroscience]

<p>The cerebral cortex of the human infant at term is complexly folded in a similar fashion to adult cortex but… . . . → Read More: Similar patterns of cortical expansion during human development and evolution [Neuroscience]

miRNA malfunction causes spinal motor neuron disease [Neuroscience]

<p>Defective RNA metabolism is an emerging mechanism involved in ALS pathogenesis and possibly in other neurodegenerative disorders. Here, we show… . . . → Read More: miRNA malfunction causes spinal motor neuron disease [Neuroscience]

Prion protein interaction with stress-inducible protein 1 enhances neuronal protein synthesis via mTOR [Neuroscience]

Transmissible spongiform encephalopathies are fatal neurodegenerative diseases caused by the conversion of prion protein (PrPC) into an infectious isoform (PrPSc)…. . . . → Read More: Prion protein interaction with stress-inducible protein 1 enhances neuronal protein synthesis via mTOR [Neuroscience]

Neurofibromin regulates corticostriatal inhibitory networks during working memory performance [Neuroscience]

<p>Neurofibromatosis type I (NF1) is one of the most common single-gene causes of learning disabilities. Here, we use behavioral working… . . . → Read More: Neurofibromin regulates corticostriatal inhibitory networks during working memory performance [Neuroscience]

In This Issue [This Week in PNAS]

. . . → Read More: In This Issue [This Week in PNAS]