Dynamic Ca2+-Dependent Stimulation of Vesicle Fusion by Membrane-Anchored Synaptotagmin 1

Han-Ki Lee,  Yoosoo Yang,  Zengliu Su,  Changbong Hyeon, Tae-Sun Lee, Hong-Won Lee, Dae-Hyuk Kweon, Yeon-Kyun Shin,  Tae-Young Yoon

In neurons, synaptotagmin 1 (Syt1) is thought to mediate the fusion of synaptic vesicles with the plasma membrane when presynaptic Ca2+ levels rise. However, in vitro reconstitution experiments have failed to recapitulate key characteristics of . . . → Read More: Dynamic Ca2+-Dependent Stimulation of Vesicle Fusion by Membrane-Anchored Synaptotagmin 1

Altered Histone Acetylation Is Associated with Age-Dependent Memory Impairment in Mice

Shahaf Peleg,  Farahnaz Sananbenesi,  Athanasios Zovoilis,  Susanne Burkhardt, Sanaz Bahari-Javan, Roberto Carlos Agis-Balboa, Perla Cota, Jessica Lee Wittnam,  Andreas Gogol-Doering, Lennart Opitz, Gabriella Salinas-Riester, Markus Dettenhofer, Hui Kang, Laurent Farinelli, Wei Chen, André Fischer

As the human life span increases, the number of people suffering from cognitive decline is rising dramatically. The mechanisms underlying . . . → Read More: Altered Histone Acetylation Is Associated with Age-Dependent Memory Impairment in Mice