The Third Reviewer

Loss of glutamate receptor–dependent synaptic plasticity in the brain is associated with the transition to cocaine addiction.<br><br>Authors: Fernando Kasanetz, Véronique Deroche-Gamonet, Nadège Berson, Eric Balado, Mathieu Lafourcade, Olivier Manzoni, Pier Vincenzo Piazza . . . → Read More: [Report] Transition to Addiction Is Associated with a Persistent Impairment in Synaptic Plasticity

Abstract

Rosamund F. Langston, James A. Ainge, Jonathan J. Couey, Cathrin B. Canto, Tale L. Bjerknes, Menno P. Witter, Edvard I. Moser, and May-Britt Moser

In the adult brain, space and orientation are represented by an elaborate hippocampal-parahippocampal circuit consisting of head-direction cells, place cells, and grid cells. We report that a rudimentary . . . → Read More: Development of the Spatial Representation System in the Rat

Abstract

Tom J. Wills, Francesca Cacucci, Neil Burgess, and John O’Keefe

Orienting in large-scale space depends on the interaction of environmental experience and preconfigured, possibly innate, constructs. Place, head-direction, and grid cells in the hippocampal formation provide allocentric representations of space. Here we show how these cognitive representations emerge and develop as rat . . . → Read More: Development of the Hippocampal Cognitive Map in Preweanling Rats

Jamie Peters, Laura M. Dieppa-Perea, Loyda M. Melendez, and Gregory J. Quirk

The extinction of conditioned fear memories requires plasticity in the infralimbic medial prefrontal cortex (IL mPFC), but little is known about the molecular mechanisms involved. Brain-derived neurotrophic factor (BDNF) is a key mediator of synaptic plasticity in multiple brain areas. . . . → Read More: Induction of Fear Extinction with Hippocampal-Infralimbic BDNF

Meital Oren-Suissa, David H. Hall, Millet Treinin, Gidi Shemer, and Benjamin Podbilewicz

The mechanisms controlling the formation and maintenance of neuronal trees are poorly understood. We examined the dynamic development of two arborized mechanoreceptor neurons (PVDs) required for reception of strong mechanical stimuli in Caenorhabditis elegans. The PVDs elaborated dendritic trees comprising . . . → Read More: The Fusogen EFF-1 Controls Sculpting of Mechanosensory Dendrites